TY - JOUR
T1 - In vitro activity of fenticonazole against Candida and bacterial vaginitis isolates determined by mono- Or dual-species testing assays
AU - Sanguinetti, Maurizio
AU - Cantón, Emilia
AU - Torelli, Riccardo
AU - Tumietto, Fabio
AU - Espinel-Ingroff, Ana
AU - Posteraro, Brunella
PY - 2019
Y1 - 2019
N2 - We determined the in vitro activity of fenticonazole against 318 vaginitis isolates of Candida and bacterial species and selected 28 isolates for time-kill studies. At concentrations equal to 4 MIC, fenticonazole reached the 99.9% killing endpoint by 10 h for Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli and by 17 h for Candida albicans and Candida parapsilosis; and at concentrations equal to 8 MIC, by 19 and 20 h for Candida glabrata and Candida tropicalis, respectively. At concentrations equal to 2 MIC, fenticonazole required 20 h to reach the above endpoint against C. albicans in mixed culture with S. aureus, S. agalactiae, or E. coli versus 17 h against C. albicans in pure culture. Supra-MICs are achievable in topically treated patients’ vaginal surfaces.
AB - We determined the in vitro activity of fenticonazole against 318 vaginitis isolates of Candida and bacterial species and selected 28 isolates for time-kill studies. At concentrations equal to 4 MIC, fenticonazole reached the 99.9% killing endpoint by 10 h for Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli and by 17 h for Candida albicans and Candida parapsilosis; and at concentrations equal to 8 MIC, by 19 and 20 h for Candida glabrata and Candida tropicalis, respectively. At concentrations equal to 2 MIC, fenticonazole required 20 h to reach the above endpoint against C. albicans in mixed culture with S. aureus, S. agalactiae, or E. coli versus 17 h against C. albicans in pure culture. Supra-MICs are achievable in topically treated patients’ vaginal surfaces.
KW - Antimicrobial susceptibility testing
KW - Fenticonazole
KW - Targeted therapy
KW - Vaginal isolates
KW - Antimicrobial susceptibility testing
KW - Fenticonazole
KW - Targeted therapy
KW - Vaginal isolates
UR - http://hdl.handle.net/10807/140207
UR - https://aac.asm.org/content/aac/63/7/e02693-18.full.pdf
U2 - 10.1128/AAC.02693-18
DO - 10.1128/AAC.02693-18
M3 - Article
SN - 1070-6283
VL - 63
SP - 1
EP - 7
JO - ANTIMICROBIAL AGENTS AND CHEMOTHERAPY [CD-ROM]
JF - ANTIMICROBIAL AGENTS AND CHEMOTHERAPY [CD-ROM]
ER -