In search of a disease

Gustavo Savino; Andrea Campana, Md; Gianluigi Petrone; Gabriela Grimaldi; Ann P. Murchison

doi:10.1016/j.survophthal.2016.12.006

In search of a disease

Gustavo Savino, Andrea Campana, Md, Gianluigi Petrone, Gabriela Grimaldi, Ann P. Murchison

Risultato della ricerca: Contributo in rivista › Articolo

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Abstract

A 10-year-old child presented with right eyelid swelling and a palpable orbital mass. Diagnostic evaluation with the aid of excisional biopsy revealed a pseudoencapsulated mass associated with high levels of serum perinuclear antineutrophil cytoplasmic antibodies. Family history of rheumatic diseases, response to treatment with corticosteroids and immunosuppressant drugs, and clinical and histopathologic features suggested an orbital autoimmune response in which perinuclear antineutrophil cytoplasmic antibodies were detected, and a diagnosis of probable IgG4-related disease was made.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	Survey of Ophthalmology
DOI	https://doi.org/10.1016/j.survophthal.2016.12.006
Stato di pubblicazione	Pubblicato - 2016

Keywords

Intravenous steroids
Ophthalmology
Orbital IgG4-related disease
Pediatric orbital inflammatory disease
Perinuclear antineutrophil cytoplasmic antibodies (p-ANCA)
Subcutaneous methotrexate

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10.1016/j.survophthal.2016.12.006

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title = "In search of a disease",

abstract = "A 10-year-old child presented with right eyelid swelling and a palpable orbital mass. Diagnostic evaluation with the aid of excisional biopsy revealed a pseudoencapsulated mass associated with high levels of serum perinuclear antineutrophil cytoplasmic antibodies. Family history of rheumatic diseases, response to treatment with corticosteroids and immunosuppressant drugs, and clinical and histopathologic features suggested an orbital autoimmune response in which perinuclear antineutrophil cytoplasmic antibodies were detected, and a diagnosis of probable IgG4-related disease was made.",

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author = "Gustavo Savino and {Campana, Md}, Andrea and Gianluigi Petrone and Gabriela Grimaldi and Murchison, {Ann P.}",

year = "2016",

doi = "10.1016/j.survophthal.2016.12.006",

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TY - JOUR

T1 - In search of a disease

AU - Savino, Gustavo

AU - Campana, Md, Andrea

AU - Petrone, Gianluigi

AU - Grimaldi, Gabriela

AU - Murchison, Ann P.

PY - 2016

Y1 - 2016

N2 - A 10-year-old child presented with right eyelid swelling and a palpable orbital mass. Diagnostic evaluation with the aid of excisional biopsy revealed a pseudoencapsulated mass associated with high levels of serum perinuclear antineutrophil cytoplasmic antibodies. Family history of rheumatic diseases, response to treatment with corticosteroids and immunosuppressant drugs, and clinical and histopathologic features suggested an orbital autoimmune response in which perinuclear antineutrophil cytoplasmic antibodies were detected, and a diagnosis of probable IgG4-related disease was made.

AB - A 10-year-old child presented with right eyelid swelling and a palpable orbital mass. Diagnostic evaluation with the aid of excisional biopsy revealed a pseudoencapsulated mass associated with high levels of serum perinuclear antineutrophil cytoplasmic antibodies. Family history of rheumatic diseases, response to treatment with corticosteroids and immunosuppressant drugs, and clinical and histopathologic features suggested an orbital autoimmune response in which perinuclear antineutrophil cytoplasmic antibodies were detected, and a diagnosis of probable IgG4-related disease was made.

KW - Intravenous steroids

KW - Ophthalmology

KW - Orbital IgG4-related disease

KW - Pediatric orbital inflammatory disease

KW - Perinuclear antineutrophil cytoplasmic antibodies (p-ANCA)

KW - Subcutaneous methotrexate

KW - Intravenous steroids

KW - Ophthalmology

KW - Orbital IgG4-related disease

KW - Pediatric orbital inflammatory disease

KW - Perinuclear antineutrophil cytoplasmic antibodies (p-ANCA)

KW - Subcutaneous methotrexate

UR - http://hdl.handle.net/10807/103162

UR - http://www.sciencedirect.com/science/journal/00396257

U2 - 10.1016/j.survophthal.2016.12.006

DO - 10.1016/j.survophthal.2016.12.006

M3 - Article

SN - 0039-6257

SP - N/A-N/A

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

ER -

In search of a disease

Abstract

Keywords

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