Improving Endometrial cancer assessment by combining the new techniqUe of GENomic profiling with surgical Extra uterIne disEase assessment (EUGENIE)

Jenneke C. Kasius, Rita Trozzi, Johanna Pijnenborg, Thaïs Baert, Annouschka Laenen, Anne-Sophie Van Rompuy, Ignacio Zapardiel, Giuseppe Vizzielli, Jure Knez, Francesco Fanfani, Frédéric Amant

Risultato della ricerca: Contributo in rivistaAbstract

Abstract

Background The molecular classification of endometrial cancer revolutionized our knowledge of its biology but so far has not affected our surgical approach. The exact risk of extra-uterine metastasis and hence the type of surgical staging for each of the four molecular subgroups are currently unknown. Primary Objective To determine the association between molecular classification and disease stage. Study Hypothesis Each endometrial cancer molecular subgroup has a specific pattern of spread and this pattern of spread could guide the extent of surgical staging. Trial Design Prospective, multicenter study Major Inclusion/Exclusion Criteria Participants eligible for inclusion in this study must meet all the following criteria: women ≥18 years with primary endometrial cancer, any histology and stage. Primary Endpoint Number and site of metastasis in each endometrial cancer molecular subgroup. Sample Size 1000 patients will be enrolled. Estimated Dates for Completing Accrual and Presenting Results The trial will last 6 years: 4 years of accrual, and 2 years of follow-up of all patients. Results on staging and oncological outcomes are expected in 2027 and 2029, respectively. Trial Registration The study has been accepted by UZ Leuven Ethical Committee. Belg. Reg. nr: B3222022000997
Lingua originaleEnglish
pagine (da-a)823-826
Numero di pagine4
RivistaInternational Journal of Gynecological Cancer
Volume33
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • Endometrial Neoplasms
  • Gynecologic Surgical Procedures

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