Improved glycemic control with weight loss and a low risk of hypoglycemia with insulin detemir: insights from the Italian cohort of the Predictive study after 6-month observatiob in type 2 diabetic subjects

Salvatore Caputo, Francesco Zaccardi, G Perriello, G De Pergola, A Di Carlo, G Grassi, A Lapolla, P Pata, Sb Solerte

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

OBJECTIVE: PREDICTIVE (Predictable Results and Experience in Diabetes through Intensification and Control to Target: an International Variability Evaluation) is a large, multinational, open-label, prospective, observational study addressed to assess the efficacy and safety of insulin detemir in clinical practice. This paper reports 26 weeks of follow-up data, from 1298 type 2 diabetes patients from Italy. RESEARCH DESIGN AND METHODS: In this observational study, the primary end point was the incidence of serious adverse drug reactions (SADRs), including major hypoglycemia. Secondary end points were: hemoglobin A1c (HbA1c), mean self-monitored fasting glucose, within-patient fasting glucose variability and body weight change. RESULTS: Insulin detemir significantly improved glycemic control, with a decrease in mean HbA1c, fasting glucose and within-patient fasting glucose variability. Interestingly, the improvements in glycemic control occurred in association with a small, but significant reduction in weight. The safety results of this study showed that 26 weeks of treatment with insulin detemir was associated with a very low rate of SADRs (only 14 events), which mainly consisted of hypoglycemia (78%, of which 42% were major hypoglycemia). CONCLUSIONS: Insulin detemir improves glycemic control, with low risk of hypoglycemia, no weight gain and an excellent safety profile; these data support the overall findings of PREDICTIVE.
Lingua originaleEnglish
pagine (da-a)2449-2455
Numero di pagine7
RivistaExpert Opinion in Pharmacotherapy
Volume12
Stato di pubblicazionePubblicato - 2011

Keywords

  • Detemir
  • Insulin

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