TY - JOUR
T1 - Improved Detection of Minimal Residual Disease by 11C-Methionine PET/CT in a Young Patient with Unusual Extramedullary Presentation of Recurrent Multiple Myeloma
AU - Caldarella, Carmelo
AU - Annunziata, Salvatore
AU - Pagano, Livio
AU - De Stefano, Valerio
AU - Rufini, Vittoria
PY - 2017
Y1 - 2017
N2 - Extramedullary relapse of multiple myeloma (MM) is uncommon. A 40-year-old woman with history of MM underwent PET/CT using 11 C-methionine (C-MET) after the detection of a vulvar lesion on MRI, biopsy proven to be extramedullary relapse of MM. The vulvar lesion was negative at the 18F-FDG PET/CT but showed high uptake of C-MET; focal uptake of both 18F-FDG and C-MET was shown within the muscles of the left leg, histologically confirmed as extramedullary relapse of MM. 18F-FDG PET/CT performed after chemotherapy showed no uptake in both sites, whereas posttreatment C-MET PET/CT showed persistence of residual uptake within the vulvar lesion.
AB - Extramedullary relapse of multiple myeloma (MM) is uncommon. A 40-year-old woman with history of MM underwent PET/CT using 11 C-methionine (C-MET) after the detection of a vulvar lesion on MRI, biopsy proven to be extramedullary relapse of MM. The vulvar lesion was negative at the 18F-FDG PET/CT but showed high uptake of C-MET; focal uptake of both 18F-FDG and C-MET was shown within the muscles of the left leg, histologically confirmed as extramedullary relapse of MM. 18F-FDG PET/CT performed after chemotherapy showed no uptake in both sites, whereas posttreatment C-MET PET/CT showed persistence of residual uptake within the vulvar lesion.
KW - 11 C-methionine PET/CT
KW - Radiology, Nuclear Medicine and Imaging
KW - extramedullary myeloma relapse
KW - improved detection
KW - unusual site
KW - 11 C-methionine PET/CT
KW - Radiology, Nuclear Medicine and Imaging
KW - extramedullary myeloma relapse
KW - improved detection
KW - unusual site
UR - http://hdl.handle.net/10807/93248
UR - http://journals.lww.com/nuclearmed/pages/default.aspx
U2 - 10.1097/RLU.0000000000001462
DO - 10.1097/RLU.0000000000001462
M3 - Article
SN - 0363-9762
VL - 42
SP - e130-e134
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
ER -