Impetigo herpetiformis occurring during N-butyl-scopolammonium bromide therapy in pregnancy: case report

Cristina Guerriero, Sara Lanza Silveri, Teresa Sisto, Donatella Rosati, Clara De Simone, Barbara Fossati, Francesco Pomini, Maurizio Rotoli, Pierluigi Amerio, Rodolfo Capizzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)


Impetigo herpetiformis (IH) is a rare dermatosis arising during the third trimester of pregnancy which is generally considered as a form of pustular psoriasis of unknown aetiology. Clinically it is characterized by erythematous plaques surrounded by sterile pustules associated with fever, diarrhea, sweating and increasing risk of stillbirth for placental insufficiency. We describe a case of developed erythematous plaques surrounded by pustules localised initially to the trunk of a 35-year-old woman at the 34th week of gestation after 5 days of treatment with N-Butyl-Scopolammonium, and which later involved the upper and lower limbs. Skin histology confirmed the diagnosis of generalised pregnancy pustular psoriasis (impetigo herpetiformis). IH is reported to be associated with hypocalcemia, hypoparathyroidism, use of oral contraceptives and bacterial infections. This is the first report suggesting the potential role of drugs other than oral contraceptives in the pathogenetic mechanism of this disease. In this case an adverse cutaneous reaction to BB could be the cause of the development of Koebner isomorphism.
Lingua originaleEnglish
pagine (da-a)141-144
Numero di pagine4
Stato di pubblicazionePubblicato - 2008


  • Adult
  • Butylscopolammonium Bromide
  • Dermatitis Herpetiformis
  • Female
  • Humans
  • Impetigo
  • Male
  • Pregnancy


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