Impaired coronary and myocardial flow in severe aortic stenosis is associated with increased apoptosis

Leonarda Galiuto, Filippo Crea, Fabio De Giorgio, Marzia Lotrionte, Amedeo Anselmi, Antonio Abbate, Giuseppe Biondi Zoccai, A Baldi, F Baldi, G Possati, M Gaudino, Gw Vetrovec

Risultato della ricerca: Contributo in rivistaArticolo in rivista

36 Citazioni (Scopus)

Abstract

OBJECTIVE: To test the hypothesis that impaired coronary and myocardial blood flow are linked with increased myocyte apoptosis, thus establishing a link between pressure overload and left ventricular (LV) remodelling. METHODS AND RESULTS: Peak diastolic coronary blood flow velocity (CBFV) was evaluated at transthoracic Doppler echocardiography, and signal intensity (SI) and the rate of SI rise (beta) were measured at myocardial contrast echocardiography in 11 patients with severe aortic stenosis and LV hypertrophy. In the same patients, biopsies were obtained from the anterolateral LV free wall during surgery and analysed for cardiomyocyte apoptosis. LV mass corrected CBFV (CBFVI) was significantly lower in patients than in controls (median 0.100 cm.g/s (interquartile range 0.07-0.115) v 0.130 cm.g/s (0.130-0.160), p = 0.002). Similarly, SI*beta was significantly lower in patients than in controls (11 1/s (8-66) v 83 1/s (73-95), p = 0.001). Apoptotic rate was increased in aortic stenosis more than 100-fold versus controls (1.2% (0.8-1.4) v 0.01% (0.01-0.01), p < 0.001) and inversely correlated with lower CBFVI and SI*beta (r = -0.77, p = 0.001 for both). CONCLUSIONS: Patients with severe aortic stenosis and LV hypertrophy have impaired myocardial perfusion, which is associated with enhanced cardiomyocyte apoptosis. Impaired myocardial perfusion and the ensuing oxygen demand-supply imbalance may, at least partially, be responsible for increased apoptosis and possible transition to heart failure, thus establishing a link between pressure overload, LV remodelling, and heart failure.
Lingua originaleEnglish
pagine (da-a)208-212
Numero di pagine5
RivistaHeart
Stato di pubblicazionePubblicato - 2006

Keywords

  • aortic stenosis
  • apoptosis

Fingerprint

Entra nei temi di ricerca di 'Impaired coronary and myocardial flow in severe aortic stenosis is associated with increased apoptosis'. Insieme formano una fingerprint unica.

Cita questo