Impaired bactericidal and fungicidal activities of neutrophils in patients with myelodysplastic syndrome

Brunella Posteraro, Maurizio Sanguinetti, Livio Pagano, Luana Fianchi, Giuseppe Leone, Francesco Guidi, Caterina Giovanna Valentini, Maria Teresa Voso

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

22 Citazioni (Scopus)

Abstract

Infections are a major cause of morbidity and mortality in patients with myelodysplastic syndrome (MDS) due to quantitative and qualitative granulocytic defects. We evaluated the in vitro bactericidal and fungicidal activities of neutrophils isolated from MDS. With comparison to those from healthy individuals, MDS neutrophils following infection showed a significantly reduced killing activity against Escherichia coli at 8 (p=0.002), 24 (p<0.0001), 48 (p=0.0005), and 72 h (p=0.0264), against Lactococcus lactis at 24 (p=0.0002), 48 (p<0.0001), and 72 h (p<0.0001), and more against Candida albicans at 8 (p=0.0003), 24 (p<0.0001), 48 (p<0.0001), and 72 h (p<0.0001). Our data show that MDS neutrophils have an impaired microbicidal function, which might account for the high susceptibility to infections of MDS patients.
Lingua originaleEnglish
pagine (da-a)331-333
Numero di pagine3
RivistaLeukemia Research
Volume36
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Bactericidal Activity
  • Candida albicans
  • Case-Control Studies
  • Cells, Cultured
  • Escherichia coli
  • Female
  • Humans
  • Lactococcus lactis
  • Leukemia, Myelomonocytic, Chronic
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes
  • Neutrophils
  • Prognosis
  • Risk Factors

Fingerprint Entra nei temi di ricerca di 'Impaired bactericidal and fungicidal activities of neutrophils in patients with myelodysplastic syndrome'. Insieme formano una fingerprint unica.

Cita questo