TY - JOUR
T1 - Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease
AU - Rosso, Chiara
AU - Caviglia, Gian Paolo
AU - Birolo, Giovanni
AU - Armandi, Angelo
AU - Pennisi, Grazia
AU - Pelusi, Serena
AU - Younes, Ramy
AU - Liguori, Antonio
AU - Perez-Diaz-Del-Campo, Nuria
AU - Nicolosi, Aurora
AU - Govaere, Olivier
AU - Castelnuovo, Gabriele
AU - Olivero, Antonella
AU - Abate, Maria Lorena
AU - Ribaldone, Davide Giuseppe
AU - Fariselli, Piero
AU - Valenti, Luca
AU - Miele, Luca
AU - Petta, Salvatore
AU - Romero-Gomez, Manuel
AU - Anstee, Quentin M
AU - Bugianesi, Elisabetta
PY - 2023
Y1 - 2023
N2 - Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65-109 months). We stratified the study cohort according to sex, body mass index (BMI)
AB - Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65-109 months). We stratified the study cohort according to sex, body mass index (BMI)
KW - Liver-Related Outcomes
KW - NAFLD
KW - NASH
KW - PNPLA3
KW - Liver-Related Outcomes
KW - NAFLD
KW - NASH
KW - PNPLA3
UR - https://publicatt.unicatt.it/handle/10807/244934
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85162915919&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85162915919&origin=inward
U2 - 10.1016/j.cgh.2023.04.024
DO - 10.1016/j.cgh.2023.04.024
M3 - Article
SN - 1542-3565
SP - N/A-N/A
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - may
ER -