Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease

Chiara Rosso; Gian Paolo Caviglia; Giovanni Birolo; Angelo Armandi; Grazia Pennisi; Serena Pelusi; Ramy Younes; Antonio Liguori; Nuria Perez-Diaz-Del-Campo; Aurora Nicolosi; Olivier Govaere; Gabriele Castelnuovo; Antonella Olivero; Maria Lorena Abate; Davide Giuseppe Ribaldone; Piero Fariselli; Luca Valenti; Luca Miele; Salvatore Petta; Manuel Romero-Gomez; Quentin M Anstee; Elisabetta Bugianesi

doi:10.1016/j.cgh.2023.04.024

Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease

Chiara Rosso
, Gian Paolo Caviglia
, Giovanni Birolo
, Angelo Armandi
, Grazia Pennisi
, Serena Pelusi
, Ramy Younes
, Antonio Liguori
, Nuria Perez-Diaz-Del-Campo
, Aurora Nicolosi
, Olivier Govaere
, Gabriele Castelnuovo
, Antonella Olivero
, Maria Lorena Abate
, Davide Giuseppe Ribaldone
, Piero Fariselli
, Luca Valenti
, Luca Miele
, Salvatore Petta
, Manuel Romero-Gomez

Quentin M Anstee, Elisabetta Bugianesi^*

^*Autore corrispondente per questo lavoro

University of Turin
Johannes Gutenberg University Mainz
University of Palermo
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
Boehringer Ingelheim GmbH
Newcastle University
University of Milan
Hospital Universitario Virgen del Rocio

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65-109 months). We stratified the study cohort according to sex, body mass index (BMI)

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	Clinical Gastroenterology and Hepatology
Numero di pubblicazione	may
DOI	https://doi.org/10.1016/j.cgh.2023.04.024
Stato di pubblicazione	Pubblicato - 2023

All Science Journal Classification (ASJC) codes

Epatologia
Gastroenterologia

Keywords

Liver-Related Outcomes
NAFLD
NASH
PNPLA3

Accesso al documento

10.1016/j.cgh.2023.04.024

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Rosso, C., Caviglia, G. P., Birolo, G., Armandi, A., Pennisi, G., Pelusi, S., Younes, R., Liguori, A., Perez-Diaz-Del-Campo, N., Nicolosi, A., Govaere, O., Castelnuovo, G., Olivero, A., Abate, M. L., Ribaldone, D. G., Fariselli, P., Valenti, L., Miele, L., Petta, S., ... Bugianesi, E. (2023). Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease. Clinical Gastroenterology and Hepatology, (may), N/A-N/A. https://doi.org/10.1016/j.cgh.2023.04.024

@article{747906ab13104b8dade155a4021bedb8,

title = "Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease",

abstract = "Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65-109 months). We stratified the study cohort according to sex, body mass index (BMI)",

keywords = "Liver-Related Outcomes, NAFLD, NASH, PNPLA3, Liver-Related Outcomes, NAFLD, NASH, PNPLA3",

author = "Chiara Rosso and Caviglia, \{Gian Paolo\} and Giovanni Birolo and Angelo Armandi and Grazia Pennisi and Serena Pelusi and Ramy Younes and Antonio Liguori and Nuria Perez-Diaz-Del-Campo and Aurora Nicolosi and Olivier Govaere and Gabriele Castelnuovo and Antonella Olivero and Abate, \{Maria Lorena\} and Ribaldone, \{Davide Giuseppe\} and Piero Fariselli and Luca Valenti and Luca Miele and Salvatore Petta and Manuel Romero-Gomez and Anstee, \{Quentin M\} and Elisabetta Bugianesi",

year = "2023",

doi = "10.1016/j.cgh.2023.04.024",

language = "English",

pages = "N/A--N/A",

journal = "Clinical Gastroenterology and Hepatology",

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publisher = "W.B. Saunders",

number = "may",

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Rosso, C, Caviglia, GP, Birolo, G, Armandi, A, Pennisi, G, Pelusi, S, Younes, R, Liguori, A, Perez-Diaz-Del-Campo, N, Nicolosi, A, Govaere, O, Castelnuovo, G, Olivero, A, Abate, ML, Ribaldone, DG, Fariselli, P, Valenti, L, Miele, L, Petta, S, Romero-Gomez, M, Anstee, QM & Bugianesi, E 2023, 'Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease', Clinical Gastroenterology and Hepatology, n. may, pagg. N/A-N/A. https://doi.org/10.1016/j.cgh.2023.04.024

TY - JOUR

T1 - Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease

AU - Rosso, Chiara

AU - Caviglia, Gian Paolo

AU - Birolo, Giovanni

AU - Armandi, Angelo

AU - Pennisi, Grazia

AU - Pelusi, Serena

AU - Younes, Ramy

AU - Liguori, Antonio

AU - Perez-Diaz-Del-Campo, Nuria

AU - Nicolosi, Aurora

AU - Govaere, Olivier

AU - Castelnuovo, Gabriele

AU - Olivero, Antonella

AU - Abate, Maria Lorena

AU - Ribaldone, Davide Giuseppe

AU - Fariselli, Piero

AU - Valenti, Luca

AU - Miele, Luca

AU - Petta, Salvatore

AU - Romero-Gomez, Manuel

AU - Anstee, Quentin M

AU - Bugianesi, Elisabetta

PY - 2023

Y1 - 2023

N2 - Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65-109 months). We stratified the study cohort according to sex, body mass index (BMI)

AB - Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65-109 months). We stratified the study cohort according to sex, body mass index (BMI)

KW - Liver-Related Outcomes

KW - NAFLD

KW - NASH

KW - PNPLA3

KW - Liver-Related Outcomes

KW - NAFLD

KW - NASH

KW - PNPLA3

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U2 - 10.1016/j.cgh.2023.04.024

DO - 10.1016/j.cgh.2023.04.024

M3 - Article

SN - 1542-3565

SP - N/A-N/A

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - may

ER -

Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Accesso al documento

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