Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation

Giuliano Giorgio Cerulli, Franco Pandolfi, M Nicoletti, G Neri, G Maccauro, D Tripodi, G Varvara, A Saggini, G Potalivo, Ml Castellani, M Fulcheri, M Rosati, E Toniato, A Caraffa, P Antinolfi, R Galzio, P Conti, Tc Theoharides

Risultato della ricerca: Contributo in rivistaArticolo in rivista

16 Citazioni (Scopus)


There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.
Lingua originaleEnglish
pagine (da-a)849-857
Numero di pagine9
RivistaInternational Journal of Immunopathology and Pharmacology
Stato di pubblicazionePubblicato - 2012


  • Animals
  • Arachidonic Acid
  • Capillary Permeability
  • Dinoprostone
  • Humans
  • Receptors, Neurokinin-1
  • Substance P


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