Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation

M. Nicoletti, G. Neri, Giulio Maccauro, D. Tripodi, G. Varvara, A. Saggini, G. Potalivo, M. L. Castellani, M. Fulcheri, M. Rosati, E. Toniato, A. Caraffa, P. Antinolfi, G. Cerulli, Giuliano Giorgio Cerulli, Franco Pandolfi, R. Galzio, P. Conti, T. C. Theoharides

Risultato della ricerca: Contributo in rivistaArticolo in rivista

16 Citazioni (Scopus)


There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.
Lingua originaleEnglish
pagine (da-a)849-857
Numero di pagine9
RivistaInternational Journal of Immunopathology and Pharmacology
Stato di pubblicazionePubblicato - 2012


  • Animals
  • Arachidonic Acid
  • Capillary Permeability
  • Dinoprostone
  • Humans
  • Receptors, Neurokinin-1
  • Substance P


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