Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma

Gabriele Molteni; Riccardo Nocini; Francesco Mattioli; Meijin Nakayama; Rogerio A. Dedivitis; Giuditta Mannelli; Erika Crosetti; Carlos Miguel Chiesa-Estomba; Jon A. Sistiaga-Suarez; Leone Giordano; Andrea Galli; Marco Lionello; Giuseppe Mercante; Massimo Ralli; Matteo Fermi; Alejandro Klein-Rodríguez; Miguel Mayo-Yáñez; Edoardo Serafini; Francesca Pirola; Alberto Paderno; Francesca Cambria; Nobuhiko Oridate; Daisuke Sano; Paolo Boscolo-Rizzo; Alberto Vito Marcuzzo; Giampiero Parrinello; Filippo Marchi; Alberto Maria Saibene; Manuel Tucciarone; Guillem Viscasillas; Karol Zeleník; Daniel Marin Ramos; Jose Palacios-Garcia; Giancarlo Tirelli; Raul Pellini; Gaetano Paludetti; Jacopo Galli; Giorgia Rossi; Marco De Vincentiis; Claudio Roberto Cernea; Giuseppe Spriano; Mario Bussi; Giorgio Peretti; Giovanni Succo; Cesare Piazza; Andy Bertolin; Luiz Paulo Kowalski; Livio Presutti; Andrea Sacchetto

doi:10.1002/hed.27471

Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma

Gabriele Molteni
, Riccardo Nocini
, Francesco Mattioli
, Meijin Nakayama
, Rogerio A. Dedivitis
, Giuditta Mannelli
, Erika Crosetti
, Carlos Miguel Chiesa-Estomba
, Jon A. Sistiaga-Suarez
, Leone Giordano
, Andrea Galli
, Marco Lionello
, Giuseppe Mercante
, Massimo Ralli
, Matteo Fermi
, Alejandro Klein-Rodríguez
, Miguel Mayo-Yáñez
, Edoardo Serafini
, Francesca Pirola
, Alberto Paderno

Francesca Cambria, Nobuhiko Oridate, Daisuke Sano, Paolo Boscolo-Rizzo, Alberto Vito Marcuzzo, Giampiero Parrinello, Filippo Marchi, Alberto Maria Saibene, Manuel Tucciarone, Guillem Viscasillas, Karol Zeleník, Daniel Marin Ramos, Jose Palacios-Garcia, Giancarlo Tirelli, Raul Pellini, Gaetano Paludetti, Jacopo Galli, Giorgia Rossi, Marco De Vincentiis, Claudio Roberto Cernea, Giuseppe Spriano, Mario Bussi, Giorgio Peretti, Giovanni Succo, Cesare Piazza, Andy Bertolin, Luiz Paulo Kowalski, Livio Presutti, Andrea Sacchetto

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Introduction: The aim of this study is to assess the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. Materials and methods: We conducted a retrospective multicenter international study involving 24 Otorhinolaryngology-Head and Neck Surgery divisions. Disease-specific survival (DSS) and disease-free survival (DFS) were evaluated as the main outcomes. The curves for DSS and DFS according to NPLN and LNR were analyzed to identify significant variations and establish specific cut-off values. Results: 2507 patients met the inclusion criteria. DSS and DFS were significantly different in the groups of patients stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN demonstrated an improved ability to stratify patients when compared to pN staging. Conclusion: Our data demonstrate the potential prognostic value of NPLN and LNR in laryngeal squamous cell carcinoma.

Lingua originale	Inglese
pagine (da-a)	2274-2293
Numero di pagine	20
Rivista	HEAD & NECK
Volume	45
DOI	https://doi.org/10.1002/hed.27471
Stato di pubblicazione	Pubblicato - 2023

Keywords

laryngeal cancer
lymph node
lymph node metastasis
lymph node ratio
oncology

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Molteni, G., Nocini, R., Mattioli, F., Nakayama, M., Dedivitis, R. A., Mannelli, G., Crosetti, E., Chiesa-Estomba, C. M., Sistiaga-Suarez, J. A., Giordano, L., Galli, A., Lionello, M., Mercante, G., Ralli, M., Fermi, M., Klein-Rodríguez, A., Mayo-Yáñez, M., Serafini, E., Pirola, F., ... Sacchetto, A. (2023). Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma. HEAD & NECK, 45, 2274-2293. https://doi.org/10.1002/hed.27471

@article{799db4b00f9d4860abee5addb93d7e57,

title = "Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma",

abstract = "Introduction: The aim of this study is to assess the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. Materials and methods: We conducted a retrospective multicenter international study involving 24 Otorhinolaryngology-Head and Neck Surgery divisions. Disease-specific survival (DSS) and disease-free survival (DFS) were evaluated as the main outcomes. The curves for DSS and DFS according to NPLN and LNR were analyzed to identify significant variations and establish specific cut-off values. Results: 2507 patients met the inclusion criteria. DSS and DFS were significantly different in the groups of patients stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN demonstrated an improved ability to stratify patients when compared to pN staging. Conclusion: Our data demonstrate the potential prognostic value of NPLN and LNR in laryngeal squamous cell carcinoma.",

keywords = "laryngeal cancer, lymph node, lymph node metastasis, lymph node ratio, oncology, laryngeal cancer, lymph node, lymph node metastasis, lymph node ratio, oncology",

author = "Gabriele Molteni and Riccardo Nocini and Francesco Mattioli and Meijin Nakayama and Dedivitis, \{Rogerio A.\} and Giuditta Mannelli and Erika Crosetti and Chiesa-Estomba, \{Carlos Miguel\} and Sistiaga-Suarez, \{Jon A.\} and Leone Giordano and Andrea Galli and Marco Lionello and Giuseppe Mercante and Massimo Ralli and Matteo Fermi and Alejandro Klein-Rodr{\'i}guez and Miguel Mayo-Y{\'a}{\~n}ez and Edoardo Serafini and Francesca Pirola and Alberto Paderno and Francesca Cambria and Nobuhiko Oridate and Daisuke Sano and Paolo Boscolo-Rizzo and Marcuzzo, \{Alberto Vito\} and Giampiero Parrinello and Filippo Marchi and Saibene, \{Alberto Maria\} and Manuel Tucciarone and Guillem Viscasillas and Karol Zelen{\'i}k and Ramos, \{Daniel Marin\} and Jose Palacios-Garcia and Giancarlo Tirelli and Raul Pellini and Gaetano Paludetti and Jacopo Galli and Giorgia Rossi and \{De Vincentiis\}, Marco and Cernea, \{Claudio Roberto\} and Giuseppe Spriano and Mario Bussi and Giorgio Peretti and Giovanni Succo and Cesare Piazza and Andy Bertolin and Kowalski, \{Luiz Paulo\} and Livio Presutti and Andrea Sacchetto",

year = "2023",

doi = "10.1002/hed.27471",

language = "English",

volume = "45",

pages = "2274--2293",

journal = "HEAD \& NECK",

issn = "1097-0347",

publisher = "[New York, NY] : Wiley Periodicals, Inc., c1989-",

}

Molteni, G, Nocini, R, Mattioli, F, Nakayama, M, Dedivitis, RA, Mannelli, G, Crosetti, E, Chiesa-Estomba, CM, Sistiaga-Suarez, JA, Giordano, L, Galli, A, Lionello, M, Mercante, G, Ralli, M, Fermi, M, Klein-Rodríguez, A, Mayo-Yáñez, M, Serafini, E, Pirola, F, Paderno, A, Cambria, F, Oridate, N, Sano, D, Boscolo-Rizzo, P, Marcuzzo, AV, Parrinello, G, Marchi, F, Saibene, AM, Tucciarone, M, Viscasillas, G, Zeleník, K, Ramos, DM, Palacios-Garcia, J, Tirelli, G, Pellini, R, Paludetti, G, Galli, J, Rossi, G, De Vincentiis, M, Cernea, CR, Spriano, G, Bussi, M, Peretti, G, Succo, G, Piazza, C, Bertolin, A, Kowalski, LP, Presutti, L & Sacchetto, A 2023, 'Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma', HEAD & NECK, vol. 45, pagg. 2274-2293. https://doi.org/10.1002/hed.27471

TY - JOUR

T1 - Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma

AU - Molteni, Gabriele

AU - Nocini, Riccardo

AU - Mattioli, Francesco

AU - Nakayama, Meijin

AU - Dedivitis, Rogerio A.

AU - Mannelli, Giuditta

AU - Crosetti, Erika

AU - Chiesa-Estomba, Carlos Miguel

AU - Sistiaga-Suarez, Jon A.

AU - Giordano, Leone

AU - Galli, Andrea

AU - Lionello, Marco

AU - Mercante, Giuseppe

AU - Ralli, Massimo

AU - Fermi, Matteo

AU - Klein-Rodríguez, Alejandro

AU - Mayo-Yáñez, Miguel

AU - Serafini, Edoardo

AU - Pirola, Francesca

AU - Paderno, Alberto

AU - Cambria, Francesca

AU - Oridate, Nobuhiko

AU - Sano, Daisuke

AU - Boscolo-Rizzo, Paolo

AU - Marcuzzo, Alberto Vito

AU - Parrinello, Giampiero

AU - Marchi, Filippo

AU - Saibene, Alberto Maria

AU - Tucciarone, Manuel

AU - Viscasillas, Guillem

AU - Zeleník, Karol

AU - Ramos, Daniel Marin

AU - Palacios-Garcia, Jose

AU - Tirelli, Giancarlo

AU - Pellini, Raul

AU - Paludetti, Gaetano

AU - Galli, Jacopo

AU - Rossi, Giorgia

AU - De Vincentiis, Marco

AU - Cernea, Claudio Roberto

AU - Spriano, Giuseppe

AU - Bussi, Mario

AU - Peretti, Giorgio

AU - Succo, Giovanni

AU - Piazza, Cesare

AU - Bertolin, Andy

AU - Kowalski, Luiz Paulo

AU - Presutti, Livio

AU - Sacchetto, Andrea

PY - 2023

Y1 - 2023

N2 - Introduction: The aim of this study is to assess the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. Materials and methods: We conducted a retrospective multicenter international study involving 24 Otorhinolaryngology-Head and Neck Surgery divisions. Disease-specific survival (DSS) and disease-free survival (DFS) were evaluated as the main outcomes. The curves for DSS and DFS according to NPLN and LNR were analyzed to identify significant variations and establish specific cut-off values. Results: 2507 patients met the inclusion criteria. DSS and DFS were significantly different in the groups of patients stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN demonstrated an improved ability to stratify patients when compared to pN staging. Conclusion: Our data demonstrate the potential prognostic value of NPLN and LNR in laryngeal squamous cell carcinoma.

AB - Introduction: The aim of this study is to assess the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. Materials and methods: We conducted a retrospective multicenter international study involving 24 Otorhinolaryngology-Head and Neck Surgery divisions. Disease-specific survival (DSS) and disease-free survival (DFS) were evaluated as the main outcomes. The curves for DSS and DFS according to NPLN and LNR were analyzed to identify significant variations and establish specific cut-off values. Results: 2507 patients met the inclusion criteria. DSS and DFS were significantly different in the groups of patients stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN demonstrated an improved ability to stratify patients when compared to pN staging. Conclusion: Our data demonstrate the potential prognostic value of NPLN and LNR in laryngeal squamous cell carcinoma.

KW - laryngeal cancer

KW - lymph node

KW - lymph node metastasis

KW - lymph node ratio

KW - oncology

KW - laryngeal cancer

KW - lymph node

KW - lymph node metastasis

KW - lymph node ratio

KW - oncology

UR - http://hdl.handle.net/10807/303933

U2 - 10.1002/hed.27471

DO - 10.1002/hed.27471

M3 - Article

SN - 1097-0347

VL - 45

SP - 2274

EP - 2293

JO - HEAD & NECK

JF - HEAD & NECK

ER -

Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma

Abstract

Keywords

OSS delle Nazioni Unite

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