TY - JOUR
T1 - Impact of highly active antiretroviral therapy (HAART) on the incidence of bacterial infections in HIV infected subjects
AU - De Gaetano Donati, Katleen
AU - Tumbarello, Mario
AU - Tacconelli, Evelina
AU - Bertagnolio, Silvia
AU - Rabagliati, Ricardo
AU - Scoppettuolo, Giancarlo
AU - Citton, Rita
AU - Cataldo, Maria
AU - Rastrelli, Elena
AU - Fadda, Giovanni
AU - Cauda, Roberto
PY - 2003
Y1 - 2003
N2 - The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) on the incidence of bacterial infections in HIV-infected patients. Two time periods were compared: (A) January 1992-December 1995 (before HAART) and (B) January 1997-December 2000 (after HAART). During the study periods, we observed 931 patients with bacterial infections, i.e. 322 with bacteremia, 369 with bacterial pneumonia and 240 with urinary tract infections, out of 4,242 HIV-infected subjects admitted to the Department of Infectious Diseases of a large university hospital. By comparing the overall incidence of bacterial infections during periods A and B, a statistically significant difference, from 32% to 18% (p<0.01), was observed. Analysis of risk factors of community- and hospital-acquired bacterial infections did not significantly differ in the two study periods. This study establishes that a significant reduction in bacterial infection incidence occurred in HIV-infected subjects when HAART became the standard therapy for HIV infection.
AB - The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) on the incidence of bacterial infections in HIV-infected patients. Two time periods were compared: (A) January 1992-December 1995 (before HAART) and (B) January 1997-December 2000 (after HAART). During the study periods, we observed 931 patients with bacterial infections, i.e. 322 with bacteremia, 369 with bacterial pneumonia and 240 with urinary tract infections, out of 4,242 HIV-infected subjects admitted to the Department of Infectious Diseases of a large university hospital. By comparing the overall incidence of bacterial infections during periods A and B, a statistically significant difference, from 32% to 18% (p<0.01), was observed. Analysis of risk factors of community- and hospital-acquired bacterial infections did not significantly differ in the two study periods. This study establishes that a significant reduction in bacterial infection incidence occurred in HIV-infected subjects when HAART became the standard therapy for HIV infection.
KW - HAART
KW - HIV infection
KW - bacterial infections
KW - HAART
KW - HIV infection
KW - bacterial infections
UR - http://hdl.handle.net/10807/12777
M3 - Article
SN - 1120-009X
VL - 2003
SP - 60
EP - 65
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
ER -
