TY - JOUR
T1 - Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy
AU - Eapen, Mary
AU - Klein, John P.
AU - Ruggeri, Annalisa
AU - Spellman, Stephen
AU - Lee, Stephanie J.
AU - Anasetti, Claudio
AU - Arcese, William
AU - Barker, Juliet N.
AU - Lee, Ann Baxter-Lowe
AU - Brown, Maria
AU - Fernandez-Vina, Marcelo A.
AU - Freeman, John
AU - He, Wensheng
AU - Iori, Anna Paola
AU - Horowitz, Mary M.
AU - Locatelli, Franco
AU - Marino, Susana
AU - Maiers, Martin
AU - Michel, Gerard
AU - Sanz, Guillermo F.
AU - Gluckman, Eliane
AU - Rocha, Vanderson
PY - 2014
Y1 - 2014
N2 - We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 alleles. In a subset, allele-level HLA match was assigned using imputation; concordance between HLA-match assignment and outcome correlation was confirmed between the actual and imputed HLA-match groups. Compared with HLA-matched units, neutrophil recovery was lower with mismatches at 3, 4, or 5, but not 1 or 2 alleles. NRM was higher with units mismatched at 1, 2, 3, 4, or 5 alleles compared with HLA-matched units. The observed effects are independent of cell dose and patient age. These data support allele-level HLA matching in the selection of single UCB units.
AB - We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 alleles. In a subset, allele-level HLA match was assigned using imputation; concordance between HLA-match assignment and outcome correlation was confirmed between the actual and imputed HLA-match groups. Compared with HLA-matched units, neutrophil recovery was lower with mismatches at 3, 4, or 5, but not 1 or 2 alleles. NRM was higher with units mismatched at 1, 2, 3, 4, or 5 alleles compared with HLA-matched units. The observed effects are independent of cell dose and patient age. These data support allele-level HLA matching in the selection of single UCB units.
KW - N/A
KW - N/A
UR - http://hdl.handle.net/10807/242556
U2 - 10.1182/blood-2013-05-506253
DO - 10.1182/blood-2013-05-506253
M3 - Article
SN - 1528-0020
VL - 123
SP - 133
EP - 140
JO - Blood
JF - Blood
ER -
