Immunohistochemical-scintigraphy correlation of sympathetic cardiac innervation in postischemic left ventricular aneurysms

Mario Fulvio Luigi Gaudino, Alessandro Giordano, Carlo Trani, Francesco Alessandrini, Simona Gaudino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

8 Citazioni (Scopus)

Abstract

Background. This study was conceived to explore the correspondence between scintigraphic imaging of the sympathetic innervation of human postischemic left ventricular aneurysms and direct immunohistochemical localization of the nerve fibers in the same area. Methods and Results. In 7 patients undergoing left ventricular aneurysmectomy for postischemic ventricular aneurysm, the findings of thallium 201 and metaiodobenzylguanidine myocardial scintigraphy were compared with direct immunohistochemical localization of the nerve fibers in the same area. This comparison showed good correspondence between scintigraphic and immunohistochemical data, although scintigraphy failed to detect areas of minimal sympathetic innervation. Moreover, microscopic analysis showed sympathetic nerve fibers with peculiar morphology and distribution in the aneurysmal zone. Conclusions. There is a good correspondence between immunohistochemical and scintigraphic imaging in the detection of sympathetic cardiac nerves in human left ventricular aneurysms; a morphologically abnormal sympathetic reinnervation can be found in the aneurysmal area (although denervation can persist in some zones).
Lingua originaleEnglish
pagine (da-a)601-607
Numero di pagine7
RivistaJournal of Nuclear Cardiology
Volume9
DOI
Stato di pubblicazionePubblicato - 2002

Keywords

  • 3-Iodobenzylguanidine
  • Aged
  • Aneurysm
  • Female
  • Heart Aneurysm
  • Heart Ventricles
  • Humans
  • Hypoxia-Ischemia, Brain
  • Immunohistochemistry
  • Iodine 123 metaiodobenzylguanidine
  • Male
  • Middle Aged
  • Preoperative Care
  • Radioisotopes
  • Radionuclide Imaging
  • Reproducibility of Results
  • Scintigraphy
  • Sensitivity and Specificity
  • Statistics as Topic
  • Sympathetic Nervous System
  • Thalium 201
  • Thallium
  • Vasomotor System
  • Ventricular Dysfunction, Left

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