Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Massimiliano Fabbiani; Simona Di Giambenedetto; Michela Sali; S Farina; Paola Sansonetti; Enrica Tamburrini; Lorenzo Zileri Dal Verme; Giovanni Delogu; Andrea De Luca; D Kelvin; Roberto Cauda; Guido Fadda

doi:10.1016/j.vaccine.2011.02.020

Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Massimiliano Fabbiani, Simona Di Giambenedetto, Michela Sali, S Farina, Paola Sansonetti, Enrica Tamburrini, Lorenzo Zileri Dal Verme, Giovanni Delogu, Andrea De Luca, D Kelvin, Roberto Cauda, Guido Fadda

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.

Lingua originale	English
pagine (da-a)	2836-2839
Numero di pagine	4
Rivista	Vaccine
Volume	29
DOI	https://doi.org/10.1016/j.vaccine.2011.02.020
Stato di pubblicazione	Pubblicato - 2011

Keywords

Adjuvants, Immunologic
Adult
Antibodies, Viral
CD4 Lymphocyte Count
Female
HIV
HIV Infections
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza A Virus, H1N1 Subtype
Influenza Vaccines
Influenza, Human
Male
Middle Aged
Polysorbates
Squalene

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10.1016/j.vaccine.2011.02.020

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title = "Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients",

abstract = "Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.",

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author = "Massimiliano Fabbiani and {Di Giambenedetto}, Simona and Michela Sali and S Farina and Paola Sansonetti and Enrica Tamburrini and {Zileri Dal Verme}, Lorenzo and Giovanni Delogu and {De Luca}, Andrea and D Kelvin and Roberto Cauda and Guido Fadda",

year = "2011",

doi = "10.1016/j.vaccine.2011.02.020",

language = "English",

volume = "29",

pages = "2836--2839",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010",

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T1 - Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

AU - Fabbiani, Massimiliano

AU - Di Giambenedetto, Simona

AU - Sali, Michela

AU - Farina, S

AU - Sansonetti, Paola

AU - Tamburrini, Enrica

AU - Zileri Dal Verme, Lorenzo

AU - Delogu, Giovanni

AU - De Luca, Andrea

AU - Kelvin, D

AU - Cauda, Roberto

AU - Fadda, Guido

PY - 2011

Y1 - 2011

N2 - Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.

AB - Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.

KW - Adjuvants, Immunologic

KW - Adult

KW - Antibodies, Viral

KW - CD4 Lymphocyte Count

KW - Female

KW - HIV

KW - HIV Infections

KW - Hemagglutinin Glycoproteins, Influenza Virus

KW - Humans

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza Vaccines

KW - Influenza, Human

KW - Male

KW - Middle Aged

KW - Polysorbates

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KW - Adult

KW - Antibodies, Viral

KW - CD4 Lymphocyte Count

KW - Female

KW - HIV

KW - HIV Infections

KW - Hemagglutinin Glycoproteins, Influenza Virus

KW - Humans

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza Vaccines

KW - Influenza, Human

KW - Male

KW - Middle Aged

KW - Polysorbates

KW - Squalene

UR - http://hdl.handle.net/10807/13712

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DO - 10.1016/j.vaccine.2011.02.020

M3 - Article

SN - 0264-410X

VL - 29

SP - 2836

EP - 2839

JO - Vaccine

JF - Vaccine

ER -

Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Abstract

Keywords

OSS delle Nazioni Unite

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