Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Simona Di Giambenedetto, Michela Sali, Enrica Tamburrini, Giovanni Delogu, Roberto Cauda, Massimiliano Fabbiani, Paola Sansonetti, Lorenzo Zileri Dal Verme, Andrea De Luca, Guido Fadda, S Farina, D Kelvin

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.
Lingua originaleEnglish
pagine (da-a)2836-2839
Numero di pagine4
RivistaVACCINE
Volume29
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Adjuvants, Immunologic
  • Adult
  • Antibodies, Viral
  • CD4 Lymphocyte Count
  • Female
  • HIV
  • HIV Infections
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Humans
  • Influenza A Virus, H1N1 Subtype
  • Influenza Vaccines
  • Influenza, Human
  • Male
  • Middle Aged
  • Polysorbates
  • Squalene

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