Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Massimiliano Fabbiani; Simona Di Giambenedetto; Michela Sali; Soraya Farina; Paola Sansonetti; Enrica Tamburrini; Lz Dal Verme; Giovanni Delogu; Andrea De Luca; D Kelvin; Roberto Cauda; Giovanni Fadda

doi:10.1016/j.vaccine.2011.02.020

Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Massimiliano Fabbiani
, Simona Di Giambenedetto
, Michela Sali
, Soraya Farina
, Paola Sansonetti
, Enrica Tamburrini
, Lz Dal Verme
, Giovanni Delogu
, Andrea De Luca
, D Kelvin
, Roberto Cauda
, Giovanni Fadda

University Health Network University of Toronto
Azienda Ospedaliera Universitaria Senese

Risultato della ricerca: Contributo in rivista › Articolo

27 Citazioni (Scopus)

Abstract

Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.

Lingua originale	Inglese
pagine (da-a)	2836-2839
Numero di pagine	4
Rivista	Vaccine
Volume	29
Numero di pubblicazione	16
DOI	https://doi.org/10.1016/j.vaccine.2011.02.020
Stato di pubblicazione	Pubblicato - 2011

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Keywords

Adjuvants
Adult
Antibodies
CD4 Lymphocyte Count
Female
H1N1 Subtype
HIV
HIV Infections
Hemagglutinin Glycoproteins
Human
Humans
Immunologic
Influenza
Influenza A Virus
Influenza Vaccines
Influenza Virus
Male
Middle Aged
Polysorbates
Squalene
Viral

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10.1016/j.vaccine.2011.02.020

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title = "Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients",

abstract = "Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.",

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author = "Massimiliano Fabbiani and \{Di Giambenedetto\}, Simona and Michela Sali and Soraya Farina and Paola Sansonetti and Enrica Tamburrini and \{Dal Verme\}, Lz and Giovanni Delogu and \{De Luca\}, Andrea and D Kelvin and Roberto Cauda and Giovanni Fadda",

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AU - Fabbiani, Massimiliano

AU - Di Giambenedetto, Simona

AU - Sali, Michela

AU - Farina, Soraya

AU - Sansonetti, Paola

AU - Tamburrini, Enrica

AU - Dal Verme, Lz

AU - Delogu, Giovanni

AU - De Luca, Andrea

AU - Kelvin, D

AU - Cauda, Roberto

AU - Fadda, Giovanni

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AB - Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.

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Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Abstract

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Keywords

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