TY - JOUR
T1 - Immune-Guided Therapy of COVID-19
AU - Ferraccioli, Gianfranco
AU - Gremese, Elisa
AU - Goletti, Delia
AU - Petrone, Linda
AU - Cantini, Fabrizio
AU - Ugel, Stefano
AU - Canè, Stefania
AU - Bronte, Vincenzo
PY - 2022
Y1 - 2022
N2 - Vaccination has been a game changer in our efforts to address the coronavirus disease 2019 (COVID-19) pandemic. However, the disease might still represent a clinical crisis for several more years, in part because of the inevitable emergence of variants capable of evading the preexisting immunity. Drugs affecting viral spread will help curtail transmission, but therapeutics are needed to treat the more severe cases requiring hospitalization. A deep analysis of the evolving immune landscape of COVID-19 suggests that understanding the molecular bases of the distinct clinical stages is paramount if we are to limit the burden of inflammation, which can lead to death in frail individuals, according to age, sex, and comorbidities. Different phases can be defined using immune biomarkers and need specific therapeutic approaches, tailored to the underlying immune contexture.
AB - Vaccination has been a game changer in our efforts to address the coronavirus disease 2019 (COVID-19) pandemic. However, the disease might still represent a clinical crisis for several more years, in part because of the inevitable emergence of variants capable of evading the preexisting immunity. Drugs affecting viral spread will help curtail transmission, but therapeutics are needed to treat the more severe cases requiring hospitalization. A deep analysis of the evolving immune landscape of COVID-19 suggests that understanding the molecular bases of the distinct clinical stages is paramount if we are to limit the burden of inflammation, which can lead to death in frail individuals, according to age, sex, and comorbidities. Different phases can be defined using immune biomarkers and need specific therapeutic approaches, tailored to the underlying immune contexture.
KW - COVID19
KW - Therapy
KW - COVID19
KW - Therapy
UR - http://hdl.handle.net/10807/208804
U2 - 10.1158/2326-6066.CIR-21-0675
DO - 10.1158/2326-6066.CIR-21-0675
M3 - Article
SN - 2326-6066
VL - 10
SP - 384
EP - 402
JO - Cancer immunology research
JF - Cancer immunology research
ER -