Immune dyscrasia in adult growth hormone deficiency: Evaluation of hemolytic complement activity (CH50) and IgG subclasses

Antonio Mancini, Edoardo Vergani, Carmine Bruno, Cecilia Napodano, Annunziata Stefanile, Umberto Basile, Francesca Gulli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

CH50 is a screening assay for the activation of the classical complement pathway, the immunoglobulins-mediated one, activated in several inflammatory diseases. Adult growth hormone deficiency (aGHD) is recognized as a chronic inflammatory condition, although poorly evaluated under the profile of inflammatory biomarkers. The aim of this case-control observational study is to analyze CH50 and immunoglobulins G (IgG) subclasses production in aGHD, comparing this condition to healthy controls. 38 subjects were included and divided as follows: aGHD (n = 18, 6 females and 12 males); healthy controls (n = 20, 10 females and 10 males). GHD was diagnosed with dynamic test using Growth Hormone-Releasing Hormone (GHRH 50 μg i.v. + arginine 0,5 g/Kg), with a peak GH response < 9 μg/L when BMI was <30 kg/m2 or < 4 μg/L when BMI was >30 kg/m2. The two groups were evaluated for hormonal and metabolic parameters, CH50 and IgG subtypes. IgG1 and IgG2 were significantly higher in controls than in aGHD, while IgG3 and IgG4 showed a trend to higher levels in controls, although not significant. Furthermore, CH50 levels were significantly higher in aGHD. These data substantiate the hypothesis of a dyscrasia in IgG subclasses production in aGHD. As IgG levels decrease, CH50 levels do not.
Lingua originaleEnglish
pagine (da-a)110757-N/A
RivistaBIOMÉDECINE &amp; PHARMACOTHÉRAPIE
Volume131
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Adult
  • Arginine
  • Body Mass Index
  • CH50
  • Case-Control Studies
  • Complement Hemolytic Activity Assay
  • Complement System Proteins
  • Female
  • Free light chains
  • GHD
  • Growth Hormone-Releasing Hormone
  • Human Growth Hormone
  • Humans
  • Immunoglobulin G
  • Immunoglobulins
  • Low grade chronic inflammation
  • Male
  • Middle Aged

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