TY - JOUR
T1 - Immediate effects of rhythmic auditory stimulation on gait kinematics in Parkinson's disease ON/OFF medication
AU - Erra, Carmen
AU - Mileti, Ilaria
AU - Germanotta, M.
AU - Germanotta, Marco
AU - Petracca, Martina
AU - Imbimbo, Isabella
AU - De Biase, Alessandro
AU - Rossi, Stefano
AU - Ricciardi, Diego
AU - Pacilli, Alessandra
AU - Di Sipio, Enrica
AU - Palermo, Eduardo
AU - Bentivoglio, Anna Rita
AU - Padua, Luca
PY - 2019
Y1 - 2019
N2 - OBJECTIVE:
Gait impairment is a highly disabling symptom for Parkinson's disease (PD) patients. Rhythmic auditory stimulation (RAS), has shown to improve spatio-temporal gait parameters in PD, but only a few studies have focused on their effects on gait kinematics, and the ideal stimulation frequency has still not been identified.
METHODS:
We enrolled 30 PD patients and 18 controls. Patients were evaluated under two conditions (with (ON), and without (OFF) medications) with three different RAS frequencies (90%, 100%, and 110% of the patient's preferred walking cadence). Spatial-temporal parameters, joint angles and gait phases distribution were evaluated. A novel global index (GPQI) was used to quantify the difference in gait phase distribution.
RESULTS:
Along with benefits in spatial-temporal parameters, GPQI improved significantly with RAS at a frequency of 110% for both ON and OFF medication conditions. In the most severe patients, the same result was observed also with RAS at 100%.
CONCLUSIONS:
RAS administration, at a frequency of 110% of the preferred walking frequency, can be beneficial in improving the gait pattern in PD patients.
SIGNIFICANCE:
When rhythmic auditory stimulation is provided to patients with PD, the selection of an adequate frequency of stimulation can optimize their effects on gait pattern.
AB - OBJECTIVE:
Gait impairment is a highly disabling symptom for Parkinson's disease (PD) patients. Rhythmic auditory stimulation (RAS), has shown to improve spatio-temporal gait parameters in PD, but only a few studies have focused on their effects on gait kinematics, and the ideal stimulation frequency has still not been identified.
METHODS:
We enrolled 30 PD patients and 18 controls. Patients were evaluated under two conditions (with (ON), and without (OFF) medications) with three different RAS frequencies (90%, 100%, and 110% of the patient's preferred walking cadence). Spatial-temporal parameters, joint angles and gait phases distribution were evaluated. A novel global index (GPQI) was used to quantify the difference in gait phase distribution.
RESULTS:
Along with benefits in spatial-temporal parameters, GPQI improved significantly with RAS at a frequency of 110% for both ON and OFF medication conditions. In the most severe patients, the same result was observed also with RAS at 100%.
CONCLUSIONS:
RAS administration, at a frequency of 110% of the preferred walking frequency, can be beneficial in improving the gait pattern in PD patients.
SIGNIFICANCE:
When rhythmic auditory stimulation is provided to patients with PD, the selection of an adequate frequency of stimulation can optimize their effects on gait pattern.
KW - Gait analysis
KW - Kinematic
KW - Parkinson disease
KW - Personalized medicine
KW - Rehabilitation
KW - Rhythmic auditory stimulation
KW - Gait analysis
KW - Kinematic
KW - Parkinson disease
KW - Personalized medicine
KW - Rehabilitation
KW - Rhythmic auditory stimulation
UR - http://hdl.handle.net/10807/141974
U2 - 10.1016/j.clinph.2019.07.013
DO - 10.1016/j.clinph.2019.07.013
M3 - Article
SN - 1872-8952
VL - 2019
SP - 1789
EP - 1797
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
ER -