Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review

Eleonora Nucera; Riccardo Inchingolo; Manuela Ferraironi; Arianna Aruanno; Raffaella Chini; Angela Rizzi

doi:10.12932/AP-250320-0793

Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review

Eleonora Nucera
, Riccardo Inchingolo
, Manuela Ferraironi
, Arianna Aruanno
, Raffaella Chini
, Angela Rizzi

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

BACKGROUND: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.OBJECTIVE: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.METHODS: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.RESULTS: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.CONCLUSIONS: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	Asian Pacific Journal of Allergy and Immunology
DOI	https://doi.org/10.12932/AP-250320-0793
Stato di pubblicazione	Pubblicato - 2021

Keywords

allergy, thiocolchicoside

Accesso al documento

10.12932/AP-250320-0793

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title = "Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review",

abstract = "BACKGROUND: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.OBJECTIVE: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.METHODS: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.RESULTS: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.CONCLUSIONS: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.",

keywords = "allergy, thiocolchicoside, allergy, thiocolchicoside",

author = "Eleonora Nucera and Riccardo Inchingolo and Manuela Ferraironi and Arianna Aruanno and Raffaella Chini and Angela Rizzi",

year = "2021",

doi = "10.12932/AP-250320-0793",

language = "English",

pages = "N/A--N/A",

journal = "Asian Pacific Journal of Allergy and Immunology",

issn = "0125-877X",

publisher = "Allergy and Immunology Society of Thailand",

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TY - JOUR

T1 - Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review

AU - Nucera, Eleonora

AU - Inchingolo, Riccardo

AU - Ferraironi, Manuela

AU - Aruanno, Arianna

AU - Chini, Raffaella

AU - Rizzi, Angela

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.OBJECTIVE: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.METHODS: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.RESULTS: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.CONCLUSIONS: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.

AB - BACKGROUND: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.OBJECTIVE: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.METHODS: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.RESULTS: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.CONCLUSIONS: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.

KW - allergy, thiocolchicoside

UR - http://hdl.handle.net/10807/177967

U2 - 10.12932/AP-250320-0793

DO - 10.12932/AP-250320-0793

M3 - Article

SN - 0125-877X

SP - N/A-N/A

JO - Asian Pacific Journal of Allergy and Immunology

JF - Asian Pacific Journal of Allergy and Immunology

ER -

Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review

Abstract

Keywords

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