TY - JOUR
T1 - Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review
AU - Nucera, Eleonora
AU - Inchingolo, Riccardo
AU - Ferraironi, Manuela
AU - Aruanno, Arianna
AU - Chini, Raffaella
AU - Rizzi, Angela
PY - 2021
Y1 - 2021
N2 - BACKGROUND: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.OBJECTIVE: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.METHODS: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.RESULTS: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.CONCLUSIONS: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.
AB - BACKGROUND: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.OBJECTIVE: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.METHODS: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.RESULTS: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.CONCLUSIONS: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.
KW - allergy, thiocolchicoside
KW - allergy, thiocolchicoside
UR - http://hdl.handle.net/10807/177967
U2 - 10.12932/AP-250320-0793
DO - 10.12932/AP-250320-0793
M3 - Article
SN - 0125-877X
SP - N/A-N/A
JO - Asian Pacific Journal of Allergy and Immunology
JF - Asian Pacific Journal of Allergy and Immunology
ER -