IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.

Mariapaola Marino, Carlo Provenzano, Flavia Scuderi, Emanuela Bartoccioni, J Scheller, S Rose John

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

25 Citazioni (Scopus)

Abstract

The inflammatory reaction in autoimmune polymyositis and rejection of transplanted myoblasts is characterized by mononuclear cell infiltration. In other settings monocytes are locally recruited by an IL-6-induced IL-8-to-MCP-1 switch. IL-6, upon binding to soluble gp80 (sIL-6R), can interact with membrane-bound ubiquitously expressed gp130 and activate virtually all cells (transsignaling). We found that human myoblasts could use transsignaling to produce IL-6, MCP-1 and ICAM-1; the addition of sIL-6R, binding to IL-1beta-induced IL-6, greatly increases IL-6 production. These in vitro data support the hypothesis that locally secreted IL-6 can target monocyte chemotaxis and leukocytes trafficking through an IL-6, MCP-1 and ICAM-1 modulation.
Lingua originaleEnglish
pagine (da-a)41-48
Numero di pagine8
RivistaJournal of Neuroimmunology
Volume2008
Stato di pubblicazionePubblicato - 2008

Keywords

  • IL-6
  • Muscle
  • trans-signaling

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