IL-6, monocyte infiltration and parenchymal cells

Emanuela Bartoccioni; Flavia Scuderi; Mariapaola Marino; Carlo Provenzano; Gilles Kaplanski; Valérie Marin; Catherine Farnarier

doi:10.1016/S1471-4906(03)00112-1

IL-6, monocyte infiltration and parenchymal cells

Emanuela Bartoccioni^*, Flavia Scuderi, Mariapaola Marino, Carlo Provenzano, Gilles Kaplanski, Valérie Marin, Catherine Farnarier

^*Autore corrispondente per questo lavoro

Hôpital Sainte-Marguerite

Risultato della ricerca: Contributo in rivista › Articolo in rivista

15 Citazioni (Scopus)

Abstract

The January issue of Trends in Immunology contained an interesting article by Kaplanski et al., in which the authors observed that interleukin-6 (IL-6) acts as a switch, regulating the transition from neutrophil to monocyte involvement during the inflammatory response [1]. In this model, activated polymorphonuclear (PMN) cells release soluble interleukin-6 receptor a (sIL-6Ra), which, upon binding of locally produced IL-6, combines with glycoprotein 130 (gp130) on endothelial cells, enabling them to switch from IL-8 (neutrophil-recruiting) to monocyte chemotactic protein-1 (monocyte-recruiting) secretion

Lingua originale	English
pagine (da-a)	298-299
Numero di pagine	2
Rivista	Trends in Immunology
Volume	24
DOI	https://doi.org/10.1016/S1471-4906(03)00112-1
Stato di pubblicazione	Pubblicato - 2003

Keywords

Animals
Cell Movement
Humans
Inflammation
Interleukin-6
Monocytes
Neutrophils
Signal Transduction

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10.1016/S1471-4906(03)00112-1

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abstract = "The January issue of Trends in Immunology contained an interesting article by Kaplanski et al., in which the authors observed that interleukin-6 (IL-6) acts as a switch, regulating the transition from neutrophil to monocyte involvement during the inflammatory response [1]. In this model, activated polymorphonuclear (PMN) cells release soluble interleukin-6 receptor a (sIL-6Ra), which, upon binding of locally produced IL-6, combines with glycoprotein 130 (gp130) on endothelial cells, enabling them to switch from IL-8 (neutrophil-recruiting) to monocyte chemotactic protein-1 (monocyte-recruiting) secretion",

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T1 - IL-6, monocyte infiltration and parenchymal cells

AU - Bartoccioni, Emanuela

AU - Scuderi, Flavia

AU - Marino, Mariapaola

AU - Provenzano, Carlo

AU - Kaplanski, Gilles

AU - Marin, Valérie

AU - Farnarier, Catherine

PY - 2003

Y1 - 2003

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AB - The January issue of Trends in Immunology contained an interesting article by Kaplanski et al., in which the authors observed that interleukin-6 (IL-6) acts as a switch, regulating the transition from neutrophil to monocyte involvement during the inflammatory response [1]. In this model, activated polymorphonuclear (PMN) cells release soluble interleukin-6 receptor a (sIL-6Ra), which, upon binding of locally produced IL-6, combines with glycoprotein 130 (gp130) on endothelial cells, enabling them to switch from IL-8 (neutrophil-recruiting) to monocyte chemotactic protein-1 (monocyte-recruiting) secretion

KW - Animals

KW - Cell Movement

KW - Humans

KW - Inflammation

KW - Interleukin-6

KW - Monocytes

KW - Neutrophils

KW - Signal Transduction

KW - Animals

KW - Cell Movement

KW - Humans

KW - Inflammation

KW - Interleukin-6

KW - Monocytes

KW - Neutrophils

KW - Signal Transduction

UR - http://hdl.handle.net/10807/163618

U2 - 10.1016/S1471-4906(03)00112-1

DO - 10.1016/S1471-4906(03)00112-1

M3 - Article

SN - 1471-4906

VL - 24

SP - 298

EP - 299

JO - Trends in Immunology

JF - Trends in Immunology

ER -

IL-6, monocyte infiltration and parenchymal cells

Abstract

Keywords

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