IL-6, monocyte infiltration and parenchymal cells

Mariapaola Marino, Carlo Provenzano, Emanuela Bartoccioni, Flavia Scuderi, Gilles Kaplanski, Valérie Marin, Catherine Farnarier

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

The January issue of Trends in Immunology contained an interesting article by Kaplanski et al., in which the authors observed that interleukin-6 (IL-6) acts as a switch, regulating the transition from neutrophil to monocyte involvement during the inflammatory response [1]. In this model, activated polymorphonuclear (PMN) cells release soluble interleukin-6 receptor a (sIL-6Ra), which, upon binding of locally produced IL-6, combines with glycoprotein 130 (gp130) on endothelial cells, enabling them to switch from IL-8 (neutrophil-recruiting) to monocyte chemotactic protein-1 (monocyte-recruiting) secretion
Lingua originaleEnglish
pagine (da-a)298-299
Numero di pagine2
RivistaTrends in Immunology
Volume24
DOI
Stato di pubblicazionePubblicato - 2003

Keywords

  • Animals
  • Cell Movement
  • Humans
  • Inflammation
  • Interleukin-6
  • Monocytes
  • Neutrophils
  • Signal Transduction

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