IL-6 as a druggable target in psoriasis: Focus on pustular variants

Andrea Saggini, Sergio Chimenti, Andrea Chiricozzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Psoriasis vulgaris (PV) is a cutaneous inflammatory disorder stemming from abnormal, persistent activation of the interleukin- (IL-)23/Th17 axis. Pustular psoriasis (PP) is a clinicopathological variant of psoriasis, histopathologically defined by the predominance of intraepidermal collections of neutrophils. Although PP pathogenesis is thought to largely follow that of (PV), recent evidences point to a more central role for IL-1, IL-36, and IL-6 in the development of PP. We review the role of IL-6 in the pathogenesis of PV and PP, focusing on its cross-talk with cytokines of the IL-23/Th17 axis. Clinical inhibitors of IL-6 signaling, including tocilizumab, have shown significant effectiveness in the treatment of several inflammatory rheumatic diseases, including rheumatoid arthritis and juvenile idiopathic arthritis; accordingly, anti-IL-6 agents may potentially represent future promising therapies for the treatment of PP.
Lingua originaleEnglish
pagine (da-a)1-10
Numero di pagine10
RivistaJournal of Immunology Research
Stato di pubblicazionePubblicato - 2014


  • interleukin 6
  • pustular psoriasis


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