IL-36 receptor antagonist with special emphasis on IL-38.

Y. Shaik; G. Sabatino; Giulio Maccauro; G. Varvara; G. Murmura; A. Saggini; M. Rosati; F. Conti; E. Cianchetti; A. Caraffa; P. Antinolfi; Franco Pandolfi; G. Potalivo; R. Galzio; P. Conti; T. C. Theoharides

doi:10.1177/039463201302600103

IL-36 receptor antagonist with special emphasis on IL-38.

Y. Shaik, G. Sabatino, Giulio Maccauro, G. Varvara, G. Murmura, A. Saggini, M. Rosati, F. Conti, E. Cianchetti, A. Caraffa, P. Antinolfi, Franco Pandolfi, G. Potalivo, R. Galzio, P. Conti, T. C. Theoharides

Risultato della ricerca: Contributo in rivista › Articolo in rivista

12 Citazioni (Scopus)

Abstract

IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFkB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

Lingua originale	English
pagine (da-a)	27-36
Numero di pagine	10
Rivista	International Journal of Immunopathology and Pharmacology
Volume	26
DOI	https://doi.org/10.1177/039463201302600103
Stato di pubblicazione	Pubblicato - 2013

Keywords

IL-36 receptor
IL-38

Accesso al documento

10.1177/039463201302600103

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

Shaik, Y., Sabatino, G., Maccauro, G., Varvara, G., Murmura, G., Saggini, A., Rosati, M., Conti, F., Cianchetti, E., Caraffa, A., Antinolfi, P., Pandolfi, F., Potalivo, G., Galzio, R., Conti, P., & Theoharides, T. C. (2013). IL-36 receptor antagonist with special emphasis on IL-38. International Journal of Immunopathology and Pharmacology, 26, 27-36. https://doi.org/10.1177/039463201302600103

@article{fc124a2317634e07b8d72e722f770f4e,

title = "IL-36 receptor antagonist with special emphasis on IL-38.",

abstract = "IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFkB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.",

keywords = "IL-36 receptor, IL-38, IL-36 receptor, IL-38",

author = "Y. Shaik and G. Sabatino and Giulio Maccauro and G. Varvara and G. Murmura and A. Saggini and M. Rosati and F. Conti and E. Cianchetti and A. Caraffa and P. Antinolfi and Franco Pandolfi and G. Potalivo and R. Galzio and P. Conti and Theoharides, {T. C.}",

year = "2013",

doi = "10.1177/039463201302600103",

language = "English",

volume = "26",

pages = "27--36",

journal = "International Journal of Immunopathology and Pharmacology",

issn = "0394-6320",

publisher = "SAGE Publications Inc.",

}

Shaik, Y, Sabatino, G, Maccauro, G, Varvara, G, Murmura, G, Saggini, A, Rosati, M, Conti, F, Cianchetti, E, Caraffa, A, Antinolfi, P, Pandolfi, F, Potalivo, G, Galzio, R, Conti, P & Theoharides, TC 2013, 'IL-36 receptor antagonist with special emphasis on IL-38.', International Journal of Immunopathology and Pharmacology, vol. 26, pagg. 27-36. https://doi.org/10.1177/039463201302600103

TY - JOUR

T1 - IL-36 receptor antagonist with special emphasis on IL-38.

AU - Shaik, Y.

AU - Sabatino, G.

AU - Maccauro, Giulio

AU - Varvara, G.

AU - Murmura, G.

AU - Saggini, A.

AU - Rosati, M.

AU - Conti, F.

AU - Cianchetti, E.

AU - Caraffa, A.

AU - Antinolfi, P.

AU - Pandolfi, Franco

AU - Potalivo, G.

AU - Galzio, R.

AU - Conti, P.

AU - Theoharides, T. C.

PY - 2013

Y1 - 2013

N2 - IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFkB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

AB - IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFkB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

KW - IL-36 receptor

KW - IL-38

KW - IL-36 receptor

KW - IL-38

UR - http://hdl.handle.net/10807/50554

U2 - 10.1177/039463201302600103

DO - 10.1177/039463201302600103

M3 - Article

SN - 0394-6320

VL - 26

SP - 27

EP - 36

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

ER -

IL-36 receptor antagonist with special emphasis on IL-38.

Abstract

Keywords

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo