IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset

Amelia Evoli, Anna Paola Batocchi, Fl Sciacca, C Ferri, F Veglia, F Andreetta, R Mantegazza, Ferdinando Cornelio, D Franciotta, G Piccolo, V Cosi, Lme Grimaldi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset (p=0.0044) in the whole MG group and the subgroup of CC males developed MG about 18 years earlier than males carrying other IL-1A -889 genotypes (p=0.022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2.
Lingua originaleEnglish
pagine (da-a)94-99
Numero di pagine6
RivistaJournal of Neuroimmunology
Volume122
Stato di pubblicazionePubblicato - 2002

Keywords

  • Cohort Studies
  • Genetic Predisposition to Disease
  • Interleukin-1
  • Myasthenia Gravis

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