Abstract
Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset (p=0.0044) in the whole MG group and the subgroup of CC males developed MG about 18 years earlier than males carrying other IL-1A -889 genotypes (p=0.022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2.
Lingua originale | English |
---|---|
pagine (da-a) | 94-99 |
Numero di pagine | 6 |
Rivista | Journal of Neuroimmunology |
Volume | 122 |
Stato di pubblicazione | Pubblicato - 2002 |
Keywords
- Cohort Studies
- Genetic Predisposition to Disease
- Interleukin-1
- Myasthenia Gravis