Idiopathic SIADH in young patients: don't forget the nose

Cesare Colosimo, Claudio Parrilla, Daniela Lucidi, Gianluigi Petrone, Giovanni Bastanza

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)


Olfactory neuroblastoma (ONB) is an uncommon neuroendocrine sinonasal cancer associated by many authors to ectopic production of several biologically active substances. We report a case of a 31-year-old male patient who presented with idiopathic syndrome of inappropriate secretion of antidiuretic hormone (SIADH). During diagnostic work-up, a CT scan of the head was performed and an ethmoidal ONB was detected. Endoscopical surgery followed by radiotherapy was carried out. Immediately after surgery natraemia levels normalised. Five years later the patient is disease-free. To our knowledge, 17 cases of SIADH associated to ONB have been published. In nine reports, idiopathic SIADH promptly led to the diagnosis of the sinonasal mass as in our clinical case, however, in many reports, correct diagnosis was accomplished months to years later. In young patients with idiopathic inappropriate antidiuretic hormone secretion, a neuroendocrine malignancy of the sinonasal area must be excluded.
Lingua originaleEnglish
pagine (da-a)76-79
Numero di pagine4
RivistaActa Otorhinolaryngologica Italica
Stato di pubblicazionePubblicato - 2017


  • Arginine vasopressin
  • Olfactory neuroblastoma
  • Paraneoplastic syndrome
  • Sinonasal


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