TY - JOUR
T1 - Idiopathic inflammatory myopathies evaluated by near infrared spectroscopy
AU - Caliandro, Pietro
AU - Mirabella, Massimiliano
AU - Padua, Luca
AU - Simbolotti, C
AU - De Fino, Chiara
AU - Iacovelli, Chiara
AU - Sancricca, Cristina
AU - Rossini, Paolo Maria
PY - 2014
Y1 - 2014
N2 - Introduction: We evaluated whether near infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) versus controls. IBM showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM showed reduced oxidative metabolism compared with IBM (P=0.001) and impaired ability to supply oxygen compared with PM (P= 0.03) and IBM (P= 0.001). Discussion: NIRS differentiates samples of DM and IBM patients from controls, but it cannot distinguish PM patients from a sample of healthy subjects. © 2014 Wiley Periodicals, Inc.
AB - Introduction: We evaluated whether near infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) versus controls. IBM showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM showed reduced oxidative metabolism compared with IBM (P=0.001) and impaired ability to supply oxygen compared with PM (P= 0.03) and IBM (P= 0.001). Discussion: NIRS differentiates samples of DM and IBM patients from controls, but it cannot distinguish PM patients from a sample of healthy subjects. © 2014 Wiley Periodicals, Inc.
KW - Dermatomyositis
KW - Inclusion Body Myositis
KW - Inflammatory myopathy
KW - NIRS
KW - Polymyositis
KW - Dermatomyositis
KW - Inclusion Body Myositis
KW - Inflammatory myopathy
KW - NIRS
KW - Polymyositis
UR - https://publicatt.unicatt.it/handle/10807/62754
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84929506175&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84929506175&origin=inward
U2 - 10.1002/mus.24476
DO - 10.1002/mus.24476
M3 - Article
SN - 1097-4598
VL - 51
SP - 830
EP - 837
JO - MUSCLE & NERVE
JF - MUSCLE & NERVE
IS - 6
ER -