Abstract
We investigated the association between 157 SNPs located in 75 candidate genes involved in the immune system and proxy traits for resistance to gastrointestinal nematodes in sheep. A total of 211 lambs from eight flocks were sampled. Nematode eggs per gram were counted and classified as: (i) Strongyles, (ii) Nematodirus spp., (iii) Trichuris spp. and (iv) Marshallagia marshalli. Single- and multiple-locus models were used to test the marker–trait associations. Seven significant SNPs were identified on chromosomes OAR6, 15, 16, and 19. These findings provide insights for breeding nemarode-resistant traits in low-input production systems. General linear model, fixed and random model circulating probability unification, and Bayesian-information and linkage-disequilibrium iteratively nested keyway analyses identified a significant association between the eggs per gram of Strongyles nematodes and a specific variant of the PRLR gene.
Lingua originale | English |
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pagine (da-a) | 286-290 |
Numero di pagine | 5 |
Rivista | Animal Genetics |
Volume | 55 |
DOI | |
Stato di pubblicazione | Pubblicato - 2024 |
Keywords
- candidate genes
- genomic selection
- nematodes
- local sheep
- Haemoncus contortus