Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors

Lorenza Torti; Luciana Teofili; Sara Capodimonti; Eugenia Rosa Nuzzolo; Maria Grazia Iachininoto; Giuseppina Massini; Serelina Coluzzi; Agostino Tafuri; Francesco Fiorin; Gabriella Girelli; Gina Zini Tanzi; Luigi Maria Larocca

doi:10.2450/2013.0076-13

Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors

Lorenza Torti, Luciana Teofili, Sara Capodimonti, Eugenia Rosa Nuzzolo, Maria Grazia Iachininoto, Giuseppina Massini, Serelina Coluzzi, Agostino Tafuri, Francesco Fiorin, Gabriella Girelli, Gina Zini Tanzi, Luigi Maria Larocca

Risultato della ricerca: Contributo in rivista › Articolo in rivista

9 Citazioni (Scopus)

Abstract

Frequent blood loss induces progressive depletion of iron stores, leading to iron deficiency and, ultimately, to overt iron-deficient anaemia. The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis. Since the HIF-1α(Pro-582-Ser) variant is associated with elevated trans-activation capacity of hypoxia responsive elements of target genes, we investigated whether the HIF-1α(Pro-582-Ser) polymorphism might influence the response to repeated blood withdrawals.

Lingua originale	English
pagine (da-a)	553-557
Numero di pagine	5
Rivista	Blood Transfusion
Volume	11
DOI	https://doi.org/10.2450/2013.0076-13
Stato di pubblicazione	Pubblicato - 2013

Keywords

Blood donors
O2 sensing

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10.2450/2013.0076-13

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title = "Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors",

abstract = "Frequent blood loss induces progressive depletion of iron stores, leading to iron deficiency and, ultimately, to overt iron-deficient anaemia. The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis. Since the HIF-1α(Pro-582-Ser) variant is associated with elevated trans-activation capacity of hypoxia responsive elements of target genes, we investigated whether the HIF-1α(Pro-582-Ser) polymorphism might influence the response to repeated blood withdrawals.",

keywords = "Blood donors, O2 sensing, Blood donors, O2 sensing",

author = "Lorenza Torti and Luciana Teofili and Sara Capodimonti and Nuzzolo, {Eugenia Rosa} and Iachininoto, {Maria Grazia} and Giuseppina Massini and Serelina Coluzzi and Agostino Tafuri and Francesco Fiorin and Gabriella Girelli and {Zini Tanzi}, Gina and Larocca, {Luigi Maria}",

year = "2013",

doi = "10.2450/2013.0076-13",

language = "English",

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pages = "553--557",

journal = "Blood Transfusion",

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T1 - Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors

AU - Torti, Lorenza

AU - Teofili, Luciana

AU - Capodimonti, Sara

AU - Nuzzolo, Eugenia Rosa

AU - Iachininoto, Maria Grazia

AU - Massini, Giuseppina

AU - Coluzzi, Serelina

AU - Tafuri, Agostino

AU - Fiorin, Francesco

AU - Girelli, Gabriella

AU - Zini Tanzi, Gina

AU - Larocca, Luigi Maria

PY - 2013

Y1 - 2013

N2 - Frequent blood loss induces progressive depletion of iron stores, leading to iron deficiency and, ultimately, to overt iron-deficient anaemia. The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis. Since the HIF-1α(Pro-582-Ser) variant is associated with elevated trans-activation capacity of hypoxia responsive elements of target genes, we investigated whether the HIF-1α(Pro-582-Ser) polymorphism might influence the response to repeated blood withdrawals.

AB - Frequent blood loss induces progressive depletion of iron stores, leading to iron deficiency and, ultimately, to overt iron-deficient anaemia. The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis. Since the HIF-1α(Pro-582-Ser) variant is associated with elevated trans-activation capacity of hypoxia responsive elements of target genes, we investigated whether the HIF-1α(Pro-582-Ser) polymorphism might influence the response to repeated blood withdrawals.

KW - Blood donors

KW - O2 sensing

KW - Blood donors

KW - O2 sensing

UR - http://hdl.handle.net/10807/52315

U2 - 10.2450/2013.0076-13

DO - 10.2450/2013.0076-13

M3 - Article

SN - 1723-2007

VL - 11

SP - 553

EP - 557

JO - Blood Transfusion

JF - Blood Transfusion

ER -

Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors

Abstract

Keywords

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