Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors

Luciana Teofili, Gina Zini, Luigi Maria Larocca, Lorenza Torti, Sara Capodimonti, Eugenia Rosa Nuzzolo, Maria Grazia Iachininoto, Giuseppina Massini, Serelina Coluzzi, Agostino Tafuri, Francesco Fiorin, Gabriella Girelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

Frequent blood loss induces progressive depletion of iron stores, leading to iron deficiency and, ultimately, to overt iron-deficient anaemia. The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis. Since the HIF-1α(Pro-582-Ser) variant is associated with elevated trans-activation capacity of hypoxia responsive elements of target genes, we investigated whether the HIF-1α(Pro-582-Ser) polymorphism might influence the response to repeated blood withdrawals.
Lingua originaleEnglish
pagine (da-a)553-557
Numero di pagine5
RivistaBlood Transfusion
Volume11
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Blood donors
  • O2 sensing

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