Hypersensitivity to carboplatin in children

Palma Maurizi, A Schiavetti, G Varrasso, M A Castello

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Background: Hypersensitivity reactions are rare but at times severe complications to cytostatic drugs. Procedure: The percentage of allergic reactions to carboplatin and their clinical features were evaluated in 185 children affected by different solid tumors and treated with etoposide-carboplatin chemotherapy. Allergic reactions that occurred during or immediately following etoposide infusion (5 cases, 2.8%) were excluded from the study. Results: Seventeen out of 185 patients (9.2%) suffered from allergic responses to carboplatin. The first of these occurred after an average of 10.1 courses (range, 1-23; median, 9). The risk calculated according to the number of courses is 2% at 6 courses, 11.3% at 12 courses, and 47% at more than 12 courses. Conclusions: The high risk of allergic reactions to multiple courses of carboplatin should be kept in mind when developing treatment regimens that include the drug.
Lingua originaleEnglish
pagine (da-a)183-185
Numero di pagine3
RivistaMedical and Pediatric Oncology
Volume32
DOI
Stato di pubblicazionePubblicato - 1999

Keywords

  • Adolescent
  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Carboplatin
  • Child
  • Infusions, Intravenous
  • Drug Administration Schedule
  • Drug Hypersensitivity
  • Etoposide
  • Humans
  • Infant
  • Child, Preschool

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