Hyperkinetic disorders and loss of synaptic downscaling

Paolo Calabresi, Antonio Pisani, John Rothwell, Veronica Ghiglieri, Josè A. Obeso, Barbara Picconi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

60 Citazioni (Scopus)

Abstract

Recent clinical and preclinical studies have shown that hyperkinetic disorders such as Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are all characterized by loss of the ability to reverse synaptic plasticity and an associated increase in the excitability of excitatory neuronal inputs to a range of cortical and subcortical brain areas. Moreover, these changes have been detected in humans with hyperkinetic disorders either via direct recordings from implanted deep brain electrodes or noninvasively using transcranial magnetic stimulation. Here we discuss the mechanisms underlying the loss of bidirectional plasticity and the possibility that future interventions could be devised to reverse these changes in patients with hyperkinetic movement disorders.
Lingua originaleEnglish
pagine (da-a)868-875
Numero di pagine8
RivistaNature Neuroscience
Volume19
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Animals
  • Brain
  • Huntington Disease
  • Transcranial Magnetic Stimulation
  • Parkinson Disease
  • Deep Brain Stimulation
  • Neuronal Plasticity

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