Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism-related enzymes in patients with inflammatory bowel disease

Alfredo Papa, Valerio De Stefano, Silvio Danese, Patrizia Chiusolo, Silvia Persichilli, I Casorelli, Bruno Zappacosta, Bruno Giardina, Antonio Gasbarrini, Giuseppe Leone, Giovanni Battista Gasbarrini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

74 Citazioni (Scopus)

Abstract

Patients with inflammatory bowel disease (IBD) have an increased risk of thrombotic complications. Moreover, a hypercoagulable state has been hypothesized as a contributing factor in the pathogenesis of IBD. Recently, a growing amount of interest has focused on mild-to-moderate hyperhomocysteinemia as a risk factor for thromboembolic disease. We aimed to evaluate the prevalence of hyperhomocysteinemia in patients with IBD and to investigate the contribution of genetic defects in the enzymes involved in homocysteine (Hcy) metabolism and vitamin status in determining increased levels of plasma total Hcy (tHcy).
Lingua originaleEnglish
pagine (da-a)2677-2682
Numero di pagine6
RivistaTHE AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume96
DOI
Stato di pubblicazionePubblicato - 2001

Keywords

  • Homocysteine
  • Hyperhomocysteinemia
  • Inflammatory Bowel Diseases
  • Polymorphism, Genetic
  • Prevalence

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