Hybrid artificial pancreas: islet transplantation inside membrane bioreactors

Celestino Pio Lombardi; A Urso; G Careddu; Giovanni Ghirlanda; G Catapano; Giuseppe Brisinda; Franco Ceriati; Rocco Domenico Alfonso Bellantone; Giovanni Doglietto; F. Crucitti

Hybrid artificial pancreas: islet transplantation inside membrane bioreactors

Celestino Pio Lombardi, A Urso, G Careddu, Giovanni Ghirlanda, G Catapano, Giuseppe Brisinda, Franco Ceriati, Rocco Domenico Alfonso Bellantone, Giovanni Doglietto, F. Crucitti

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

The use of pancreatic islet transplantation in membrane bioreactors put in vascular circuits aims at resetting the glucose homeostasis in diabetic or pancreatectomized patients, avoiding immune host rejection. Our experience was carried out at following stages: porcine pancreas explantation and enzymatic separation of endocrine tissue from exocrine fraction by collagenase; evaluation of islet functionality (culture tests); in vitro tests of the islets-bioreactor system, to assess the metabolic response to the glucose; in vivo evaluation to assay the haemodynamic behaviour. The trials showed a good metabolic bioreactor functionality and a decreasing incidence of coagulative problems.

Lingua originale	English
pagine (da-a)	1177-1192
Numero di pagine	16
Rivista	Biomaterials, Artificial Cells, and Immobilization Biotechnology
Volume	20
Stato di pubblicazione	Pubblicato - 1992

Keywords

Animals
Female
Glucose
Heparin
Insulin
Islets of Langerhans Transplantation
Membranes, Artificial
Swine

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abstract = "The use of pancreatic islet transplantation in membrane bioreactors put in vascular circuits aims at resetting the glucose homeostasis in diabetic or pancreatectomized patients, avoiding immune host rejection. Our experience was carried out at following stages: porcine pancreas explantation and enzymatic separation of endocrine tissue from exocrine fraction by collagenase; evaluation of islet functionality (culture tests); in vitro tests of the islets-bioreactor system, to assess the metabolic response to the glucose; in vivo evaluation to assay the haemodynamic behaviour. The trials showed a good metabolic bioreactor functionality and a decreasing incidence of coagulative problems.",

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author = "Lombardi, {Celestino Pio} and A Urso and G Careddu and Giovanni Ghirlanda and G Catapano and Giuseppe Brisinda and Franco Ceriati and Bellantone, {Rocco Domenico Alfonso} and Giovanni Doglietto and F. Crucitti",

year = "1992",

language = "English",

volume = "20",

pages = "1177--1192",

journal = "Biomaterials, Artificial Cells, and Immobilization Biotechnology",

issn = "1055-7172",

publisher = "Marcel Dekker Incorporated:270 Madison Avenue:New York, NY 10016:(800)228-1160, (212)696-9000, EMAIL: [email protected], INTERNET: http://www.dekker.com, Fax: (212)685-4540",

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TY - JOUR

T1 - Hybrid artificial pancreas: islet transplantation inside membrane bioreactors

AU - Lombardi, Celestino Pio

AU - Urso, A

AU - Careddu, G

AU - Ghirlanda, Giovanni

AU - Catapano, G

AU - Brisinda, Giuseppe

AU - Ceriati, Franco

AU - Bellantone, Rocco Domenico Alfonso

AU - Doglietto, Giovanni

AU - Crucitti, F.

PY - 1992

Y1 - 1992

N2 - The use of pancreatic islet transplantation in membrane bioreactors put in vascular circuits aims at resetting the glucose homeostasis in diabetic or pancreatectomized patients, avoiding immune host rejection. Our experience was carried out at following stages: porcine pancreas explantation and enzymatic separation of endocrine tissue from exocrine fraction by collagenase; evaluation of islet functionality (culture tests); in vitro tests of the islets-bioreactor system, to assess the metabolic response to the glucose; in vivo evaluation to assay the haemodynamic behaviour. The trials showed a good metabolic bioreactor functionality and a decreasing incidence of coagulative problems.

AB - The use of pancreatic islet transplantation in membrane bioreactors put in vascular circuits aims at resetting the glucose homeostasis in diabetic or pancreatectomized patients, avoiding immune host rejection. Our experience was carried out at following stages: porcine pancreas explantation and enzymatic separation of endocrine tissue from exocrine fraction by collagenase; evaluation of islet functionality (culture tests); in vitro tests of the islets-bioreactor system, to assess the metabolic response to the glucose; in vivo evaluation to assay the haemodynamic behaviour. The trials showed a good metabolic bioreactor functionality and a decreasing incidence of coagulative problems.

KW - Animals

KW - Female

KW - Glucose

KW - Heparin

KW - Insulin

KW - Islets of Langerhans Transplantation

KW - Membranes, Artificial

KW - Swine

KW - Animals

KW - Female

KW - Glucose

KW - Heparin

KW - Insulin

KW - Islets of Langerhans Transplantation

KW - Membranes, Artificial

KW - Swine

UR - http://hdl.handle.net/10807/12074

M3 - Article

SN - 1055-7172

VL - 20

SP - 1177

EP - 1192

JO - Biomaterials, Artificial Cells, and Immobilization Biotechnology

JF - Biomaterials, Artificial Cells, and Immobilization Biotechnology

ER -

Hybrid artificial pancreas: islet transplantation inside membrane bioreactors

Abstract

Keywords

OSS delle Nazioni Unite

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