Hybrid artificial pancreas: islet transplantation inside membrane bioreactors

Celestino Pio Lombardi, Giuseppe Brisinda, Rocco Domenico Alfonso Bellantone, Giovanni Ghirlanda, Franco Ceriati, Giovanni Doglietto, A Urso, G Careddu, G Catapano, F. Crucitti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The use of pancreatic islet transplantation in membrane bioreactors put in vascular circuits aims at resetting the glucose homeostasis in diabetic or pancreatectomized patients, avoiding immune host rejection. Our experience was carried out at following stages: porcine pancreas explantation and enzymatic separation of endocrine tissue from exocrine fraction by collagenase; evaluation of islet functionality (culture tests); in vitro tests of the islets-bioreactor system, to assess the metabolic response to the glucose; in vivo evaluation to assay the haemodynamic behaviour. The trials showed a good metabolic bioreactor functionality and a decreasing incidence of coagulative problems.
Lingua originaleEnglish
pagine (da-a)1177-1192
Numero di pagine16
RivistaBiomaterials, Artificial Cells, and Immobilization Biotechnology
Volume20
Stato di pubblicazionePubblicato - 1992

Keywords

  • Animals
  • Female
  • Glucose
  • Heparin
  • Insulin
  • Islets of Langerhans Transplantation
  • Membranes, Artificial
  • Swine

Fingerprint

Entra nei temi di ricerca di 'Hybrid artificial pancreas: islet transplantation inside membrane bioreactors'. Insieme formano una fingerprint unica.

Cita questo