Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: Results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial

Simone Garcovich, Sabine Steinke, Claudia Zeidler, Claudia Riepe, Philipp Bruland, Iñaki Soto-Rey, Michael Storck, Matthias Augustin, Svetlana Bobko, Franz J. Legat, Andrey Lvov, Laurent Misery, Nani Osada, Adam Reich, Ekin Şavk, Esther Serra-Baldrich, Markus Streit, Jacek C. Szepietowski, Wolfgang Weger, Martin DugasSonja Ständer

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)

Abstract

Background: Chronic pruritus is a multifactorial, challenging symptom of global relevance. Objective: The European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) investigation aimed to analyze the severity and humanistic burden of chronic pruritus in patients suffering from inflammatory dermatoses across Europe. Methods: Prospectively collected routine data on 552 patients (with atopic dermatitis, contact dermatitis, prurigo nodularis, psoriasis vulgaris, lichen planus, or mycosis fungoides [pruritus numeric rating scale score ≥3]) from 9 European centers (in Austria, France, Germany, Italy, Poland, Russia, Spain, Switzerland, and Turkey) were analyzed by univariate and multivariate variance analyses of various itch characteristics and quality of life (as measured by the Dermatology Life Quality Index and the ItchyQoL). Results: Duration, frequency, and intensity of pruritus (according to a numeric rating scale and visual analog scale) and related impairment of quality of life differed between European centers and dermatologic diagnoses (P <.05). The country in which the center was located had a greater impact on how patients evaluated pruritus intensity and quality of life than diagnosis did (P <.001). Limitations: One center per country was included. Conclusion: The humanistic burden of chronic pruritus in patients with inflammatory dermatoses is high. European cross-cultural factors may have a stronger influence than a specific dermatologic diagnosis on how patients rate intensity of pruritus and quality of life.
Lingua originaleEnglish
pagine (da-a)457-463.e5
RivistaJournal of the American Academy of Dermatology
Volume79
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Adult
  • Aged
  • Chronic Disease
  • Cost of Illness
  • Cross-Sectional Studies
  • Dermatitis, Atopic
  • Dermatitis, Contact
  • Europe
  • Female
  • Humans
  • Lichen Planus
  • Male
  • Middle Aged
  • Mycosis Fungoides
  • Prurigo
  • Pruritus
  • Psoriasis
  • Quality of Life
  • Severity of Illness Index
  • care situation
  • humanistic burden
  • prurigo
  • pruritus intensity
  • pruritus measurement
  • quality of life

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