Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma

F Paolini; Angelo Carbone; M Benevolo; V Silipo; F Rollo; R Covello; P Piemonte; P Frascione; Rodolfo Capizzi; C Catricalà; Alberto Venuti

doi:10.1186/1756-9966-30-108

Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma

F Paolini, Angelo Carbone, M Benevolo, V Silipo, F Rollo, R Covello, P Piemonte, P Frascione, Rodolfo Capizzi, C Catricalà, Alberto Venuti

Risultato della ricerca: Contributo in rivista › Articolo in rivista

28 Citazioni (Scopus)

Abstract

The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneous squamous cell carcinomas. However, only few reports contain data on basal cell carcinoma (BCC). The HPVs interact with many cellular proteins altering their function or the expression levels, like the p16INK4a and Akt. Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients.

Lingua originale	English
pagine (da-a)	108-108
Numero di pagine	1
Rivista	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume	30
DOI	https://doi.org/10.1186/1756-9966-30-108
Stato di pubblicazione	Pubblicato - 2011
Pubblicato esternamente	Sì

Keywords

Carcinoma, Basal Cell
DNA, Viral
Humans
Immunohistochemistry
Middle Aged
Neoplasm Proteins
Papillomaviridae
Papillomavirus Infections
Polymerase Chain Reaction
Proto-Oncogene Proteins c-akt
RNA, Messenger
Skin Neoplasms
Up-Regulation

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10.1186/1756-9966-30-108

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title = "Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma",

abstract = "The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneous squamous cell carcinomas. However, only few reports contain data on basal cell carcinoma (BCC). The HPVs interact with many cellular proteins altering their function or the expression levels, like the p16INK4a and Akt. Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients.",

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T1 - Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma

AU - Paolini, F

AU - Carbone, Angelo

AU - Benevolo, M

AU - Silipo, V

AU - Rollo, F

AU - Covello, R

AU - Piemonte, P

AU - Frascione, P

AU - Capizzi, Rodolfo

AU - Catricalà, C

AU - Venuti, Alberto

PY - 2011

Y1 - 2011

N2 - The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneous squamous cell carcinomas. However, only few reports contain data on basal cell carcinoma (BCC). The HPVs interact with many cellular proteins altering their function or the expression levels, like the p16INK4a and Akt. Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients.

AB - The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneous squamous cell carcinomas. However, only few reports contain data on basal cell carcinoma (BCC). The HPVs interact with many cellular proteins altering their function or the expression levels, like the p16INK4a and Akt. Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients.

KW - Carcinoma, Basal Cell

KW - DNA, Viral

KW - Humans

KW - Immunohistochemistry

KW - Middle Aged

KW - Neoplasm Proteins

KW - Papillomaviridae

KW - Papillomavirus Infections

KW - Polymerase Chain Reaction

KW - Proto-Oncogene Proteins c-akt

KW - RNA, Messenger

KW - Skin Neoplasms

KW - Up-Regulation

KW - Carcinoma, Basal Cell

KW - DNA, Viral

KW - Humans

KW - Immunohistochemistry

KW - Middle Aged

KW - Neoplasm Proteins

KW - Papillomaviridae

KW - Papillomavirus Infections

KW - Polymerase Chain Reaction

KW - Proto-Oncogene Proteins c-akt

KW - RNA, Messenger

KW - Skin Neoplasms

KW - Up-Regulation

UR - http://hdl.handle.net/10807/31462

U2 - 10.1186/1756-9966-30-108

DO - 10.1186/1756-9966-30-108

M3 - Article

SN - 0392-9078

VL - 30

SP - 108

EP - 108

JO - JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

JF - JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ER -

Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma

Abstract

Keywords

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