Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma

Angelo Carbone, Rodolfo Capizzi, F Paolini, M Benevolo, V Silipo, F Rollo, R Covello, P Piemonte, P Frascione, C Catricalà, A. Venuti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneous squamous cell carcinomas. However, only few reports contain data on basal cell carcinoma (BCC). The HPVs interact with many cellular proteins altering their function or the expression levels, like the p16INK4a and Akt. Our study aimed to determine the presence of different beta -HPV types and the expression of p16INK4a and Akt in BCC, the commonest NMSC, in the normal appearing perilesional skin and in forehead swab of 37 immunocompetent patients.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine79
RivistaJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume30
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Carcinoma, Basal Cell
  • DNA, Viral
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Neoplasm Proteins
  • Papillomaviridae
  • Papillomavirus Infections
  • Polymerase Chain Reaction
  • Proto-Oncogene Proteins c-akt
  • RNA, Messenger
  • Skin Neoplasms
  • Up-Regulation

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