Human NK receptors: from the molecules to the therapy of high risk leukemias

Lorenzo Moretta, Franco Locatelli, Daniela Pende, Simona Sivori, Michela Falco, Cristina Bottino, Maria Cristina Mingari, Alessandro Moretta

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Natural killer cells are important players of the innate immunity. In humans, they express HLA-class I-specific inhibitory receptors including the allotypic-specific KIR and various activating receptors. In most instances, in an autologous setting NK cells do not kill self cells. In contrast, in an allogeneic setting as the haploidentical hematopoietic stem cell transplantation to cure high risk leukemias, donor-derived NK cells may express inhibitory KIR that are not engaged by the HLA-class I alleles (KIR ligands) expressed by recipient cells. Such "alloreactive" NK cells may be responsible for the eradication of leukemia blasts escaping the preparative regimen, residual host dendritic cells and T lymphocytes, thus preventing leukemia relapse, GvHD and graft rejection, respectively. These NK-mediated effects result in a sharp improvement of the estimated 5 years survival. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Lingua originaleEnglish
pagine (da-a)1563-1567
Numero di pagine5
RivistaFEBS Letters
Stato di pubblicazionePubblicato - 2011


  • Natural killer cell
  • Killer Ig-like receptor
  • Haploidentical hematopoietic stem cell transplantation
  • High-risk leukemia
  • Activating NK receptor


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