Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

Francesca Bugli; Stefania Manzara; Riccardo Torelli; Rosalia Graffeo; Rosaria Santangelo; Paola Cattani; Giovanni Fadda

Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

Francesca Bugli
, Stefania Manzara
, Riccardo Torelli
, Rosalia Graffeo
, Rosaria Santangelo
, Paola Cattani
, Giovanni Fadda

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

Lingua originale	Inglese
pagine (da-a)	1250-1253
Numero di pagine	4
Rivista	Journal of Clinical Microbiology
Volume	42
Numero di pubblicazione	3
Stato di pubblicazione	Pubblicato - 2004

Keywords

Glycoprotein G
Human recombinant antibodies
herpes simplex

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title = "Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis",

abstract = "A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.",

keywords = "Glycoprotein G, Human recombinant antibodies, herpes simplex, Glycoprotein G, Human recombinant antibodies, herpes simplex",

author = "Francesca Bugli and Stefania Manzara and Riccardo Torelli and Rosalia Graffeo and Rosaria Santangelo and Paola Cattani and Giovanni Fadda",

year = "2004",

language = "English",

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T1 - Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

AU - Bugli, Francesca

AU - Manzara, Stefania

AU - Torelli, Riccardo

AU - Graffeo, Rosalia

AU - Santangelo, Rosaria

AU - Cattani, Paola

AU - Fadda, Giovanni

PY - 2004

Y1 - 2004

N2 - A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

AB - A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

KW - Glycoprotein G

KW - Human recombinant antibodies

KW - herpes simplex

KW - Glycoprotein G

KW - Human recombinant antibodies

KW - herpes simplex

UR - https://publicatt.unicatt.it/handle/10807/14458

M3 - Article

SN - 0095-1137

VL - 42

SP - 1250

EP - 1253

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 3

ER -

Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

Abstract

Keywords

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