Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

Francesca Bugli; Stefania Manzara; Riccardo Torelli; Rosalia Graffeo; Rosaria Santangelo; Paola Cattani Franchi; Giovanni Fadda

Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

Francesca Bugli, Stefania Manzara, Riccardo Torelli, Rosalia Graffeo, Rosaria Santangelo, Paola Cattani Franchi, Giovanni Fadda

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

Abstract

A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

Lingua originale	English
pagine (da-a)	1250-1253
Numero di pagine	4
Rivista	Journal of Clinical Microbiology
Stato di pubblicazione	Pubblicato - 2004

Keywords

Glycoprotein G
Human recombinant antibodies
herpes simplex

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

@article{81ba6edf64484971b0ee33283d76372b,

title = "Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis",

abstract = "A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.",

keywords = "Glycoprotein G, Human recombinant antibodies, herpes simplex, Glycoprotein G, Human recombinant antibodies, herpes simplex",

author = "Francesca Bugli and Stefania Manzara and Riccardo Torelli and Rosalia Graffeo and Rosaria Santangelo and {Cattani Franchi}, Paola and Giovanni Fadda",

year = "2004",

language = "English",

pages = "1250--1253",

journal = "Journal of Clinical Microbiology",

issn = "0095-1137",

publisher = "American Society for Microbiology",

}

TY - JOUR

T1 - Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

AU - Bugli, Francesca

AU - Manzara, Stefania

AU - Torelli, Riccardo

AU - Graffeo, Rosalia

AU - Santangelo, Rosaria

AU - Cattani Franchi, Paola

AU - Fadda, Giovanni

PY - 2004

Y1 - 2004

N2 - A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

AB - A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

KW - Glycoprotein G

KW - Human recombinant antibodies

KW - herpes simplex

KW - Glycoprotein G

KW - Human recombinant antibodies

KW - herpes simplex

UR - http://hdl.handle.net/10807/14458

M3 - Article

SN - 0095-1137

SP - 1250

EP - 1253

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

ER -

Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

Abstract

Keywords

Altri file e collegamenti

Fingerprint

Cita questo