Human herpesvirus 8-associated colonic Kaposi's sarcoma during vedolizumab treatment in ulcerative colitis: A case report and review of the literature

Valerio Papa, Alfredo Papa, Loris Riccardo Lopetuso

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

1 Citazioni (Scopus)

Abstract

Background: Kaposi's sarcoma (KS) is a rare vascular tumor associated with human herpesvirus (HHV)-8 infection. One of the variants of KS is defined iatrogenic and is overall reported in transplanted patient but also, although less frequently, in patients treated with long-standing immunosuppressive therapy, such as in inflammatory bowel disease including ulcerative colitis and Crohn's disease. Case presentation: Herein, we report the first case of KS in a human immunodeficiency virus (HIV)-negative 47-year old male with UC after treatment with the α4-β7 integrin inhibitor vedolizumab (VDZ). The patient underwent to colectomy for a medical refractory disease and the histological examination of the surgical specimen showed the typical findings of KS together with the HHV-8 positivity. The patient achieved a good health status, without any sign of disease recurrence. Conclusions: In the present case, we can assume that VDZ may have promoted the reactivation of a latent HHV-8 infection endowed with oncogenic potentialities and, in turn, the onset of KS. We also briefly reviewed all the cases of KS in HIV-negative patients with inflammatory bowel disease.
Lingua originaleEnglish
pagine (da-a)76-N/A
RivistaBMC Gastroenterology
Volume20
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Antibodies, Monoclonal, Humanized
  • Colectomy
  • Colitis, Ulcerative
  • Colonic Neoplasms
  • Gastrointestinal Agents
  • Herpesvirus 8, Human
  • Human Herpesvirus-8
  • Humans
  • Immunocompromised Host
  • Kaposi's sarcoma
  • Male
  • Middle Aged
  • Sarcoma, Kaposi
  • Ulcerative colitis
  • Vedolizumab

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