TY - JOUR
T1 - Human exposure to endocrine disrupting compounds: Their role in reproductive systems, metabolic syndrome and breast cancer. A review
AU - Giulivo, Monica
AU - Lopez De Alda, Miren
AU - Capri, Ettore
AU - Barceló, Damià
PY - 2016
Y1 - 2016
N2 - Endocrine disrupting chemicals (EDCs) are released into the environment from different sources. They are mainly used in packaging industries, pesticides and food constituents. Clinical evidence, experimental models, and epidemiological studies suggest that EDCs have major risks for humans by targeting different organs and systems in the body (e.g. reproductive system, breast tissue, adipose tissue, pancreas, etc.). Due to the ubiquity of human exposure to these compounds the aim of this review is to describe the most recent data on the effects induced by phthalates, bisphenol A and parabens in a critical window of exposure: in utero, during pregnancy, infants, and children. The interactions and mechanisms of toxicity of EDCs in relation to human general health problems, especially those broadening the term of endocrine disruption to ‘metabolic disruption’, should be deeply investigated. These include endocrine disturbances, with particular reference to reproductive problems and breast, testicular and ovarian cancers, and metabolic diseases such as obesity or diabetes.
AB - Endocrine disrupting chemicals (EDCs) are released into the environment from different sources. They are mainly used in packaging industries, pesticides and food constituents. Clinical evidence, experimental models, and epidemiological studies suggest that EDCs have major risks for humans by targeting different organs and systems in the body (e.g. reproductive system, breast tissue, adipose tissue, pancreas, etc.). Due to the ubiquity of human exposure to these compounds the aim of this review is to describe the most recent data on the effects induced by phthalates, bisphenol A and parabens in a critical window of exposure: in utero, during pregnancy, infants, and children. The interactions and mechanisms of toxicity of EDCs in relation to human general health problems, especially those broadening the term of endocrine disruption to ‘metabolic disruption’, should be deeply investigated. These include endocrine disturbances, with particular reference to reproductive problems and breast, testicular and ovarian cancers, and metabolic diseases such as obesity or diabetes.
KW - 2300
KW - Biochemistry
KW - 2300
KW - Biochemistry
UR - http://hdl.handle.net/10807/96412
UR - http://www.elsevier.com/inca/publications/store/6/2/2/8/2/1/index.htt
U2 - 10.1016/j.envres.2016.07.011
DO - 10.1016/j.envres.2016.07.011
M3 - Article
SN - 0013-9351
VL - 151
SP - 251
EP - 264
JO - Environmental Research
JF - Environmental Research
ER -