Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C-/- umbilical cord blood

Mariella Della Chiesa, Michela Falco, Alice Bertaina, Letizia Muccio, Claudia Alicata, Francesco Frassoni, Franco Locatelli, Lorenzo Moretta, Alessandro Moretta

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

NK cells are the first lymphoid population recovering after allogeneic hematopoietic stem cell transplantation and play a crucial role in early immunity after the graft. Recently, it has been shown that humanCMV (HCMV) infection/reactivation can deeply influence NK cell reconstitution after umbilical cord blood transplantation by accelerating the differentiation of mature NKG2A(-) killer Iglike receptor (KIR)(+) NK cells characterized by the expression of the NKG2C(-) activating receptor. In view of the hypothesis that NKG2C could be directly involved in NK cell maturation driven by HCMV infection, we analyzed the maturation and function of NK cells developing in three patients with hematological malignancies given umbilical cord blood transplantation from donors carrying a homozygous deletion of the NKG2C gene. We show that HCMV infection can drive rapid NK maturation, characterized by the expansion of CD56(dim) NKG2A(-) KIR+ cells, even in the absence of NKG2C expression. Interestingly, this expanded mature NK cell subset expressed surface-activating KIR that could trigger NK cell cytotoxicity, degranulation, and IFN-gamma release. Given the absence of NKG2C, it is conceivable that activating KIRs may play a role in the HCMV-driven NK cell maturation and that NK cells expressing activating KIRs might contribute, at least in part, to the control of infections after transplantation.
Lingua originaleEnglish
pagine (da-a)1471-1479
Numero di pagine9
RivistaTHE JOURNAL OF IMMUNOLOGY
Volume192
DOI
Stato di pubblicazionePubblicato - 2014

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