TY - JOUR
T1 - http://www.D-MELD.com, the Italian survival calculator to optimize donor to recipient matching and to identify the unsustainable matches in liver transplantation
AU - Avolio, Alfonso Wolfango
AU - Agnes, Salvatore
AU - Lirosi, Maria Carmen
AU - Romano, Maria Luisa
AU - De Waure, Chiara
PY - 2012
Y1 - 2012
N2 - Optimization of donor-recipient match is one of the exciting challenges in liver transplantation. Using algorithms obtained by the Italian D-MELD study (5256 liver transplants, 21 Centers, 2002-2009 period), a web-based survival calculator was developed. The calculator is available online at the URL http://www.D-MELD.com. The access is free. Registration and authentication are required. The website was developed using PHP scripting language on HTML platform and it is hosted by the web provider Aruba.it. For a given donor (expressed by donor age) and for three potential recipients (expressed by values of bilirubin, creatinine, INR, and by recipient age, HCV, HBV, portal thrombosis, re-transplant status), the website calculates the patient survival at 90days, 1year, 3years, and allows the identification of possible unsustainable matches (i.e. donor-recipient matches with predicted patient survival less than 50% at 5 years). This innovative approach allows the selection of the best recipient for each referred donor, avoiding the allocation of a high-risk graft to a high-risk recipient. The use of the D-MELD.com website can help transplant surgeons, hepatologists, and transplant coordinators in everyday practice of matching donors and recipients, by selecting the more appropriate recipient among various candidates with different prognostic factors.
AB - Optimization of donor-recipient match is one of the exciting challenges in liver transplantation. Using algorithms obtained by the Italian D-MELD study (5256 liver transplants, 21 Centers, 2002-2009 period), a web-based survival calculator was developed. The calculator is available online at the URL http://www.D-MELD.com. The access is free. Registration and authentication are required. The website was developed using PHP scripting language on HTML platform and it is hosted by the web provider Aruba.it. For a given donor (expressed by donor age) and for three potential recipients (expressed by values of bilirubin, creatinine, INR, and by recipient age, HCV, HBV, portal thrombosis, re-transplant status), the website calculates the patient survival at 90days, 1year, 3years, and allows the identification of possible unsustainable matches (i.e. donor-recipient matches with predicted patient survival less than 50% at 5 years). This innovative approach allows the selection of the best recipient for each referred donor, avoiding the allocation of a high-risk graft to a high-risk recipient. The use of the D-MELD.com website can help transplant surgeons, hepatologists, and transplant coordinators in everyday practice of matching donors and recipients, by selecting the more appropriate recipient among various candidates with different prognostic factors.
KW - Algorithms
KW - Decision Support Techniques
KW - Donor Selection
KW - Graft Survival
KW - Humans
KW - Internet
KW - Italy
KW - Liver Transplantation
KW - Logistic Models
KW - Prognosis
KW - Survival Analysis
KW - the unsustainable matches in liver transplantation
KW - Algorithms
KW - Decision Support Techniques
KW - Donor Selection
KW - Graft Survival
KW - Humans
KW - Internet
KW - Italy
KW - Liver Transplantation
KW - Logistic Models
KW - Prognosis
KW - Survival Analysis
KW - the unsustainable matches in liver transplantation
UR - http://hdl.handle.net/10807/40417
U2 - 10.1111/j.1432-2277.2011.01423.x
DO - 10.1111/j.1432-2277.2011.01423.x
M3 - Article
SN - 0934-0874
VL - 25
SP - 294
EP - 301
JO - Transplant International
JF - Transplant International
ER -