HSV-1 and Alzheimer's disease: more than a hypothesis

Roberto Piacentini, Giovanna De Chiara, Domenica Donatella Li Puma, Cristian Ripoli, Maria E. Marcocci, Maria Elena Marcocci, Enrico Garaci, Anna T. Palamara, Claudio Grassi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

66 Citazioni (Scopus)


Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.
Lingua originaleEnglish
pagine (da-a)97-97
Numero di pagine1
RivistaFrontiers in Pharmacology
Stato di pubblicazionePubblicato - 2014


  • Alzheimer’s disease
  • HSV-1
  • amyloid-β protein
  • recurrent infection
  • γ secretase


Entra nei temi di ricerca di 'HSV-1 and Alzheimer's disease: more than a hypothesis'. Insieme formano una fingerprint unica.

Cita questo