HSV-1 and Alzheimer's disease: more than a hypothesis

Roberto Piacentini, Domenica Donatella Li Puma, Cristian Ripoli, Claudio Grassi, Maria Elena Marcocci, Giovanna De Chiara, Maria E. Marcocci, Enrico Garaci, Anna T. Palamara

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

64 Citazioni (Scopus)

Abstract

Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.
Lingua originaleEnglish
pagine (da-a)97-97
Numero di pagine1
RivistaFrontiers in Pharmacology
Volume5
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Alzheimer’s disease
  • HSV-1
  • amyloid-β protein
  • recurrent infection
  • γ secretase

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