How to assess drug resistance in cancer stem cells

Maria Laura De Angelis; Ruggero De Maria Marchiano; Marta Baiocchi

doi:10.1007/978-1-4939-7401-6_10

How to assess drug resistance in cancer stem cells

Maria Laura De Angelis
, Ruggero De Maria Marchiano
, Marta Baiocchi^*

^*Autore corrispondente per questo lavoro

Istituto Superiore di Sanita

Risultato della ricerca: Contributo in libro › Capitolo

4 Citazioni (Scopus)

Abstract

Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.

Lingua originale	Inglese
Titolo della pubblicazione ospite	Cancer Stem Cells: Methods and Protocols, Methods in Molecular Biology,
Editore	HUMANA PRESS INC
Pagine	107-115
Numero di pagine	9
Volume	1692
ISBN (stampa)	9781493974009
DOI	https://doi.org/10.1007/978-1-4939-7401-6_10
Stato di pubblicazione	Pubblicato - 2018

All Science Journal Classification (ASJC) codes

Biologia Molecolare
Genetica

Keywords

CSC
Cancer stem cell culture
Colorectal cancer
Drug resistance
Drug screening
Genetics
In vitro assays
Molecular Biology

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abstract = "Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.",

keywords = "CSC, Cancer stem cell culture, Colorectal cancer, Drug resistance, Drug screening, Genetics, In vitro assays, Molecular Biology, CSC, Cancer stem cell culture, Colorectal cancer, Drug resistance, Drug screening, Genetics, In vitro assays, Molecular Biology",

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T1 - How to assess drug resistance in cancer stem cells

AU - De Angelis, Maria Laura

AU - De Maria Marchiano, Ruggero

AU - Baiocchi, Marta

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KW - CSC

KW - Cancer stem cell culture

KW - Colorectal cancer

KW - Drug resistance

KW - Drug screening

KW - Genetics

KW - In vitro assays

KW - Molecular Biology

KW - CSC

KW - Cancer stem cell culture

KW - Colorectal cancer

KW - Drug resistance

KW - Drug screening

KW - Genetics

KW - In vitro assays

KW - Molecular Biology

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M3 - Chapter

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EP - 115

BT - Cancer Stem Cells: Methods and Protocols, Methods in Molecular Biology,

PB - HUMANA PRESS INC

ER -

How to assess drug resistance in cancer stem cells

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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