How to assess drug resistance in cancer stem cells

Ruggero De Maria Marchiano, Maria Laura De Angelis, Marta Baiocchi

Risultato della ricerca: Contributo in libroChapter

4 Citazioni (Scopus)

Abstract

Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.
Lingua originaleEnglish
Titolo della pubblicazione ospiteCancer Stem Cells: Methods and Protocols, Methods in Molecular Biology,
Pagine107-115
Numero di pagine9
Volume1692
DOI
Stato di pubblicazionePubblicato - 2018

Serie di pubblicazioni

NomeMETHODS IN MOLECULAR BIOLOGY

Keywords

  • CSC
  • Cancer stem cell culture
  • Colorectal cancer
  • Drug resistance
  • Drug screening
  • Genetics
  • In vitro assays
  • Molecular Biology

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