How metformin acts in PCOS pregnant women: insights into insulin secretion and peripheral action at each trimester of gestation

Daniela Romualdi; Simona De Cicco; Donatella Gagliano; Matteo Busacca; Giuseppe Campagna; Antonio Lanzone; Maurizio Guido

doi:10.2337/dc12-2071

How metformin acts in PCOS pregnant women: insights into insulin secretion and peripheral action at each trimester of gestation

Daniela Romualdi, Simona De Cicco, Donatella Gagliano, Matteo Busacca, Giuseppe Campagna, Antonio Lanzone, Maurizio Guido

Risultato della ricerca: Contributo in rivista › Articolo in rivista

10 Citazioni (Scopus)

Abstract

Metformin has been reported to reduce the risk of gestational diabetes (GD) in women with polycystic ovarian syndrome (PCOS). However, little is known about the mechanisms of action of this drug during pregnancy. In the attempt to fill this gap, we performed a prospective longitudinal study providing a detailed examination of glucose and insulin metabolism in pregnant women with PCOS undergoing metformin therapy.

Lingua originale	English
pagine (da-a)	1477-1482
Numero di pagine	6
Rivista	Diabetes Care
Volume	36
DOI	https://doi.org/10.2337/dc12-2071
Stato di pubblicazione	Pubblicato - 2013

Keywords

Adolescent
Adult
Female
Humans
Hypoglycemic Agents
Insulin
Metformin
Polycystic Ovary Syndrome
Pregnancy
Pregnancy Trimesters
Prospective Studies
Young Adult

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abstract = "Metformin has been reported to reduce the risk of gestational diabetes (GD) in women with polycystic ovarian syndrome (PCOS). However, little is known about the mechanisms of action of this drug during pregnancy. In the attempt to fill this gap, we performed a prospective longitudinal study providing a detailed examination of glucose and insulin metabolism in pregnant women with PCOS undergoing metformin therapy.",

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AU - Romualdi, Daniela

AU - De Cicco, Simona

AU - Gagliano, Donatella

AU - Busacca, Matteo

AU - Campagna, Giuseppe

AU - Lanzone, Antonio

AU - Guido, Maurizio

PY - 2013

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N2 - Metformin has been reported to reduce the risk of gestational diabetes (GD) in women with polycystic ovarian syndrome (PCOS). However, little is known about the mechanisms of action of this drug during pregnancy. In the attempt to fill this gap, we performed a prospective longitudinal study providing a detailed examination of glucose and insulin metabolism in pregnant women with PCOS undergoing metformin therapy.

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KW - Pregnancy Trimesters

KW - Prospective Studies

KW - Young Adult

KW - Adolescent

KW - Adult

KW - Female

KW - Humans

KW - Hypoglycemic Agents

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JF - Diabetes Care

ER -

How metformin acts in PCOS pregnant women: insights into insulin secretion and peripheral action at each trimester of gestation

Abstract

Keywords

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