How far are we from the clinical use of placental-derived mesenchymal stem cells?

Ornella Parolini, Alessandra Fierabracci, Lorenza Lazzari, Maurizio Muraca

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (Scopus)

Abstract

In recent years, multiple studies have investigated the biology and clinical applications of mesenchymal stem cells (MSCs), trying to define their markers, and elucidate their effects in animal models. MSCs are available from different tissues, and the use of placental-derived MSCs (PMSCs) for treating a variety of disorders is on the forefront. Herein, we discuss the most recent findings regarding the standardization of their isolation procedure and phenotype, along with advantages and limitations of their use. We also discuss the safety of the placental cell products, including the issue of senescence and mutagenesis of PMSCs, and efficacy from preclinical studies.
Lingua originaleEnglish
pagine (da-a)613-617
Numero di pagine5
RivistaExpert Opinion on Biological Therapy
Volume15
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Animals
  • Cell Differentiation
  • Female
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stromal Cells
  • Placenta
  • Pregnancy
  • isolation procedure
  • phenotype
  • placenta
  • placental mesenchymal stem cells
  • safety
  • stability
  • therapeutic application
  • tumorigenesis

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