House dust mite allergy and shrimp allergy: a complex interaction

Eleonora Nucera, Francesco Ria, Teresa Musarra, G Celi, I Brusca, E Scala, D Villalta, E Pastorello, L Farioli, G Cortellini, G Deleonardi, P Galati, L Losappio, G Manzotti, B Pirovano, L Muratore, F Murzilli, F Cucinelli, M Cilia, A AruannoM F Patria, E Varin, B R Polillo, V Sargentini, O Quercia, C G Uasuf, S Zampogna, M Carollo, S Graci, R Asero

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

Summary:Background and Objective. Sensitization and allergy to shrimp among Italian house dust mite allergic patients are not well defined and were investigated in a large multicenter study. Methods. Shrimp sensitization and allergy were assessed in 526 house dust mite (HDM)-allergic patients submitted to the detection of IgE to Der p 10 and 100 atopic control not sensitized to HDM. Results. Shrimp allergy occurred in 9% of patients (vs 0% of 100 atopic controls not sensitized to HDM; p minor 0.001). Shrimp-allergic patients were less frequently hypersensitive to airborne allergens other than HDM than crustacean-tolerant subjects (35% vs 58.8%; p minor 0.005). Only 51% of tropomyosin-sensitized patients had shrimp allergy, and these showed significantly higher Der p 10 IgE levels than shrimp-tolerant ones (mean 22.2 KU/l vs 6.2 KU/l; p minor 0.05). Altogether 53% of shrimp-allergic patients did not react against tropomyosin. Conclusions. Shrimp allergy seems to occur uniquely in association with hypersensitivity to HDM allergens and tropomyosin is the main shrimp allergen but not a major one, at least in Italy. Along with tropomyosin-specific IgE levels, monosensitization to HDM seems to represent a risk factor for the development of shrimp allergy among HDM allergic patients.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaEuropean Annals of Allergy and Clinical Immunology
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • cross-reactivity
  • food allergy
  • house dust mite allergy
  • shrimp allergy

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